We recently made this set of grants (our first since starting to manage the fund), and are planning another set in February 2019. We are keen to hear from donors and potential donors about what kind of grant making you are excited about us doing, what concerns you may have, and anything in between.
Please feel free to start posting your questions from now. We will be available here and actively answering questions between roughly 2pm and 6pm PT (with some breaks) on December 20th.
Please ask different questions in separate comments, for discussion threading.
edit: Exciting news! The EA Foundation has just told us that donations to the Long-Term Future are eligible for the matching drive they're currently running. See the link for details on how to get your donation matched.
edit 2: The "official" portion of the AMA has now concluded, but feel free to post more questions; we may be able to respond to them over the coming week or two. Thanks for participating!