Malaria

The Against Malaria Foundation provides funding for distribution of bed nets to high-risk populations. As of JuneJuly 2022, GiveWell estimates that it costs $5.19 to purchase and distribute an AMF-funded net,^[3] and that a marginal donation of $4,$5,500 to AMF is expected to avert the death of a child under five.^[4][5]

1. ^{^}

   World Health Organization (2021) World Malaria Report 2021, Geneva: World Health Organization, p. 23.

2. ^{^}

   GiveWell (2018) Mass distribution of long-lasting insecticide-treated nets (LLINs), GiveWell, March.

3. ^{^}

   GiveWell (2021) Against malaria foundation, GiveWell, November.

4. ^{^}

   GiveWell (2021)(2022) How we generateproduce impact estimates, GiveWell, November 19.July. 

5. ^{^}

   For caveats, see GiveWell (2017) Cost-effectiveness, GiveWell, November.

6. ^{^}

   GiveWell (2018) Seasonal malaria chemoprevention, GiveWell, October.

7. ^{^}

   GiveWell (2020) Malaria Consortium – Seasonal malaria chemoprevention, GiveWell, November.

8. ^{^}

   Laurens, Matthew B. (2019) RTS,S/AS01 vaccine (Mosquirix™): an overview, Human Vaccines & Immunotherapeutics, vol. 16, pp. 480–489.

9. ^{^}

   Piper, Kelsey (2021) Why the WHO approval of the first malaria vaccine is a big deal, Vox, October 6.

10. ^{^}

    World Health Organization (2021) WHO recommends groundbreaking malaria vaccine for children at risk, October 6.

11. ^{^}

    Chandramohan, Daniel et al. (2021) Seasonal malaria vaccination with or without seasonal malaria chemoprevention, New England Journal of Medicine, vol. 385, pp. 1005–1017.

12. ^{^}

    Hogan, Alexandra B., Peter Winskill & Azra C. Ghani (2020) Estimated impact of RTS,S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: A modelling study, PLOS Medicine, vol. 17, e1003377.

13. ^{^}

    Open Philanthropy (2016) Foundation for the National Institutes of Health — working group on malaria gene drive testing path, Open Philanthropy, July.

14. ^{^}

    Open Philanthropy (2017) Target Malaria — gene drives for malaria control, Open Philanthropy, May.

1. ^{^}

   World Health Organization (2021) World Malaria Report 2021, Geneva: World Health Organization, p. 23.

2. ^{^}

   GiveWell (2018) Mass distribution of long-lasting insecticide-treated nets (LLINs), GiveWell, March.

3. ^{^}

   GiveWell (2021) Against malaria foundation, GiveWell, November.

4. ^{^}

   GiveWell (2021) How We Produce Impact Estimateswe generate impact estimates, GiveWell, November 19.

5. ^{^}

   For caveats, see GiveWell (2017) Cost-effectiveness, GiveWell, November.

6. ^{^}

   GiveWell (2018) Seasonal malaria chemoprevention, GiveWell, October.

7. ^{^}

   GiveWell (2020) Malaria Consortium – Seasonal malaria chemoprevention, GiveWell, November.

8. ^{^}

   Laurens, Matthew B. (2019) RTS,S/AS01 vaccine (Mosquirix™): an overview, Human Vaccines & Immunotherapeutics, vol. 16, pp. 480–489.

9. ^{^}

   Piper, Kelsey (2021) Why the WHO approval of the first malaria vaccine is a big deal, Vox, October 6.

10. ^{^}

    World Health Organization (2021) WHO recommends groundbreaking malaria vaccine for children at risk, October 6.

11. ^{^}

    Chandramohan, Daniel et al. (2021) Seasonal malaria vaccination with or without seasonal malaria chemoprevention, New England Journal of Medicine, vol. 385, pp. 1005–1017.

12. ^{^}

    Hogan, Alexandra B., Peter Winskill & Azra C. Ghani (2020) Estimated impact of RTS,S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: A modelling study, PLOS Medicine, vol. 17, e1003377.

13. ^{^}

    Open Philanthropy (2016) Foundation for the National Institutes of Health — working group on malaria gene drive testing path, Open Philanthropy, July.

14. ^{^}

    Open Philanthropy (2017) Target Malaria — gene drives for malaria control, Open Philanthropy, May.

The Against Malaria Foundation provides funding for distribution of bed nets to high-risk populations. As of June 2022, GiveWell estimates that it costs $5.19 to purchase and distribute an AMF-funded net,^[3] and that a marginal donation of $4,500 to AMF is expected to avert the death of a child under five.^[4][5]

Malaria is a life-threatening infectious disease affecting humans and other animals. It is caused by parasites spread through the bites of infected female mosquitoes. In 2019,2020, there were 229approximately 241 million cases of malaria and 409,627,000 deaths caused by this disease worldwide.worldwide from malaria.^[1]

The Against Malaria Foundation provides funding for distribution of bed nets to high-risk populations. GiveWell estimates that it costs $4.59$5.19 to purchase and distribute an AMF-funded net,^[3] and that a marginal donation of $4,106500 to AMF is expected to avert the death of a child under five.^[4][5]

1. ^{^}

   World Health Organization (2020)(2021) World Malaria Report 2020: 20 Years of Global Progress and Challenges2021, Geneva: World Health Organization, p. xiv-xv.23.

2. ^{^}

   GiveWell (2018) Mass distribution of long-lasting insecticide-treated nets (LLINs), GiveWell, March.

3. ^{^}

   GiveWell (2020)(2021) Against malaria foundation, GiveWell, November.

4. ^{^}

   GiveWell (2020)(2021) 2020 GiveWell cost-effectiveness analysis — version 2How We Produce Impact Estimates, GiveWell, November 19.

5. ^{^}

   For caveats, see GiveWell (2017) Cost-effectiveness, GiveWell, November.

6. ^{^}

   GiveWell (2018) Seasonal malaria chemoprevention, GiveWell, October.

7. ^{^}

   GiveWell (2020) Malaria Consortium – Seasonal malaria chemoprevention, GiveWell, November.

8. ^{^}

   Laurens, Matthew B. (2019) RTS,S/AS01 vaccine (Mosquirix™): an overview, Human Vaccines & Immunotherapeutics, vol. 16, pp. 480–489.

9. ^{^}

   Piper, Kelsey (2021) Why the WHO approval of the first malaria vaccine is a big deal, Vox, October 6.

10. ^{^}

    World Health Organization (2021) WHO recommends groundbreaking malaria vaccine for children at risk, October 6.

11. ^{^}

    Chandramohan, Daniel et al. (2021) Seasonal malaria vaccination with or without seasonal malaria chemoprevention, New England Journal of Medicine, vol. 385, pp. 1005–1017.

12. ^{^}

    Hogan, Alexandra B., Peter Winskill & Azra C. Ghani (2020) Estimated impact of RTS,S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: A modelling study, PLOS Medicine, vol. 17, e1003377.

13. ^{^}

    Open Philanthropy (2016) Foundation for the National Institutes of Health — working group on malaria gene drive testing path, Open Philanthropy, July.

14. ^{^}

    Open Philanthropy (2017) Target Malaria — gene drives for malaria control, Open Philanthropy, May.

Wiblin, Robert & Keiran Harris (2022) James Tibenderana on the state of the art in malaria control and elimination, 80,000 Hours, May 9.

Roser, Max (2022) Malaria: One of the leading causes of child deaths, but progress is possible and you can contribute to it, Our World in Data, March 22.

global health and development | mass distribution of long-lasting insecticide-treated nets

Gentzel, Matthew (2016) Transgenic mosquitoes , update Effective Altruism Policy Analytics, Effective Altruism Forum, August 10.

Gessner, Bradford D., David C. Wraith & Adam Finn (2016) CNS infection safety signal of RTS,S/AS01 and possible association with rabies vaccine, The Lancet, vol. 387, p. 1376.

Penny, Melissa A. et al. (2016) Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models, The Lancet, vol. 387, pp. 367–375.

Sánchez, Sebastián (2019a) Timeline of mosquito net distribution, Timelines Wiki.

Sánchez, Sebastián (2019b)(2019) Timeline of malaria vaccine, Timelines Wiki.

Malaria is a life-threatening infectious disease affecting humans and other animals. It is caused by parasites spread through the bites of infected female mosquitoes. In 2019, there were 229 million cases of malaria and 409,000 deaths caused by this disease worldwide (World Health Organization 2020: xiv-xv).worldwide.^[1]

Multiple randomized controlled trials show that mass distribution of long-lasting insecticide-treated nets reduces malaria fevers and prevents deaths from the disease (GiveWell 2018a).disease.^[2] Despite the existence of effective prevention methods, tens of millions of people are still unprotected from malaria, and the funding gap for net distributions is in the hundreds of millions of dollars.

The Against Malaria Foundation provides funding for distribution of bed nets to high-risk populations. GiveWell estimates that it costs $4.59 to purchase and distribute an AMF-funded net (GiveWell 2020),net,^[3] and that a marginal donation of $4,106 to AMF is expected to avert the death of a child under five (GiveWell 2020b; for caveats, see GiveWell 2017).five.^[4][5]

While distribution of nets is the most common method to combat malaria at present, there are other promising approaches. The Malaria Consortium works on preventing, controlling, and treating malaria and other communicable diseases in Africa and Asia. One intervention they carry out is seasonal malaria chemoprevention (SMC) programs, which seek to distribute preventive anti-malarial drugs to children under the age of five (GiveWell 2018b; 2020c).five.^[6][7]

In principle, malaria could be controlled, and ultimately eradicated, by means of an effective vaccine. RTS,S/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine approved for use by European regulators in July 2015. Among children aged 5–17 months who received 4 doses of RTS,S/AS01, efficacy was 36% over 4 years of follow-up (Laurens 2020).up.^[8] In October 2021, the World Health Organization endorsed RTS,S/AS01 for "widespread use" among children, making it the first vaccine candidate to receive that recommendation (Piper 2021).recommendation.^[9] The WHO decision was partly based on results from an ongoing pilot program started in 2019 intended to vaccinate 360,000 children per year in Malawi, Ghana and Kenya over a five-year period (World Health Organization 2021).period.^[10] A month before the WHO announcement, a randomized trial had found that a treatment combining antimalarial medication with a four-dose schedule of the RTS,S vaccine, culminating with a booster shot just before the most vulnerable season, was much more effective than either of those methods alone (Chandramohan et al. 2021).alone.^[11] In 2020, a study using a standard model of malaria transmission estimated that 4.3 million cases and 22,000 deaths in children under five could be averted annually assuming 30 million people are vaccinated, provided areas with the highest malaria burden are prioritized (Hogan, Winskill & Ghani 2020).prioritized.^[12]

Yet another approach to combat malaria is to eliminate the mosquito species responsible for spreading the disease, or to modify it genetically to render it...

In principle, malaria could be controlled, and ultimately eradicated, by means of an effective vaccine. RTS,S/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine approved for use by European regulators in July 2015. Among children aged 5–17 months who received 4 doses of RTS,S/AS01, efficacy was 36% over 4 years of follow-up (Laurens 2020). In October 2021, the World Health Organization endorsed RTS,S/AS01 for "widespread use" among children in October 2021,children, making it the first vaccine candidate to receive that recommendation (Piper 2021). The WHO decision was partly based on results from an ongoing pilot program started in 2019 intended to vaccinate 360,000 children per year in Malawi, Ghana and Kenya over a five-year period (World Health Organization 2021). A month before the WHO announcement, a randomized trial had found that a treatment combining antimalarial medication with a four-dose schedule of the RTS,S vaccine, culminating with a booster shot just before the most vulnerable season, was much more effective than either of those methods alone (Chandramohan et al. 2021). In 2020, a study using a standard model of malaria transmission estimated that 4.3 million cases and 22,000 deaths in children under five could be averted annually assuming 30 million people are vaccinated, provided areas with the highest malaria burden are prioritized (Hogan, Winskill & Ghani 2020).

In principle, malaria could be controlled, and ultimately eradicated, by means of an effective vaccine. RTS,SS/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine,vaccine approved for use by European regulators in July 2015 and endorsed by2015. Among children aged 5–17 months who received 4 doses of RTS,S/AS01, efficacy was 36% over 4 years of follow-up (Laurens 2020). In October 2021, the World Health Organization endorsed RTS,S/AS01 for "widespread use" among children in October 2021—2021, making it the first malaria vaccine candidate to receive that recommendation.recommendation (Piper 2021). The WHO decision was partly based on results from an ongoing pilot program started in 2019 intended to vaccinate 360,000 children per year in Malawi, Ghana and Kenya over a five-year period (World Health Organization 2021). A month before the WHO announcement, a randomized trial had found that a treatment combining antimalarial medication with a four-dose schedule of the RTS,S vaccine, culminating with a booster shot just before the most vulnerable season, was much more effective than either of those methods alone (Chandramohan et al. 2021). In 2020, a study using a standard model of malaria transmission estimated that 4.3 million cases and 22,000 deaths in children under five could be averted annually assuming 30 million people are vaccinated, provided areas with the highest malaria burden are prioritized (Hogan, Winskill & Ghani 2020).

Hogan, Alexandra B., Peter Winskill & Azra C. Ghani (2020) Estimated impact of RTS,S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: A modelling study, PLOS Medicine, vol. 17, p. e1003377.

Laurens, Matthew B. (2019) RTS,S/AS01 vaccine (Mosquirix™): an overview, Human Vaccines & Immunotherapeutics, vol. 16, pp. 480–489.

Piper, Kelsey (2021) Why the WHO approval of the first malaria vaccine is a big deal, Vox, October 6.