Effective Altruism Forum
EA Forum

All of mxschons's Comments + Replies

Alvea’s Story, Wins, and Challenges [Unofficial]
mxschons5mo9
1
0
2

Hey Matt,

thanks for your thoughts! 

1. I generally agree with your point on experience (wrote this in my reflection as well). Your specific examples do not track for me though. We knew that an mRNA omicron vaccine was coming. The point was, that no booster for LMICs was in the pipeline and mRNA vaccines were basically inaccessible in most parts of the world. We also were very aware of the low efficacy of plasmid vaccines but boosting with plasmid vaccines in the context of a new variant was something not tested before and the hypothesis was that it mig... (read more)

Reply
5
Matthew Stork
5mo
Thanks for the thoughtful response Max, and I appreciated your separate write-up on this subject. I do want to highlight though that in his write-up, Kyle listed the improved regulatory environment for updated mRNA vaccines as a reason why Alvea decides not to proceed with your first vaccine candidate. That's really what I was addressing with my comment. As to the second point about lack of efficacy for plasmid vaccines, I think there were different opinions on this within Alvea. One high ranking person I spoke to gave me the opinion that poor performance of a competitor COVID plasmid vaccine was due to competitor incompetence rather than an issue with plasmid vaccines themselves. That sort of comment is why I mentioned my concern that there may of been a degree of contempt among some in Alvea for big pharma. Totally agree as to the "practical" efficacy of the adenovirus vaccines though!
Coaching: Reduce Struggle and Develop Talent
mxschons3y11
0
0

Jan's enthusiasm triggered me to start with coaching. I second  deeper changes as the truly important ones to my personal coaching journey. I started coaching without having particular "issues" but quickly realized how much space between current me and best-possible me there is. Among other things ,coaching helped me to get in the habit of deliberate practice on minimizing this space. Nowadays I regularly do self-coaching sessions that have many elements of the previous "two brain" coaching sessions. 

Reply
3
SebastianSchmidt
2y
Thanks for sharing this Max!
Responsible Biorisk Reduction Workshop, Oxford May 2020
mxschons4y1
0
0

in the application form we state

Target group:
- EA aligned
- Ambitious to contribute to GCBR reduction
- Applicants from diverse backgrounds welcome

Reply
Which Community Building Projects Get Funded?
mxschons4y6
0
0

Very much appreciate the time and effort you put into this analysis. This sort of investigative journalism within the EA community seems worth funding ;)

Reply
2
AnonymousEAForumAccount
4y
Thank you very much! For what it’s worth, I think of this analysis less as “investigative journalism”, and more as “independent vetting.” And in general, I’d like to see more resources available to support both grantmakers doing their own vetting, and independent analysts doing vetting from another perspective.
EA Handbook 3.0: What content should I include?
mxschons5y4
0
0

Is there a plan to make an audio book out of the handbook? I think many people would find that useful.

Reply
EA Handbook 3.0: What content should I include?
mxschons5y4
0
0

Are there any plans to translate the handbook into the let's say 10 most popular EA languages? (thinking of spanish, german, french, russian, ...)? If not this should be a major part of the Handbook v3

Reply
Workshop: Strategy, ideas, and life paths for reducing existential risks
mxschons5y1
0
0

We might record the event and publish the files. Besides I do not know of any events like this anywhere soon.

Reply