All of Douglas Knight's Comments + Replies

There are two separate questions here. (1) Why has society not adopted this over decades and (2) Why do EA people who promote far-UVC not also promote the old technology? The second question has a precise answer.

The patents all expired by 2016, so this contradicts your claim.

I think this was wrong. I don't know where I heard the story about Clinton negotiating price discrimination, but, actually, generics already existed in 2001 before either PEPFAR or Clinton started buying. PEPFAR simply refused to use them because it wasn't actually about saving lives. It switched in 2006 because it was embarrassed by Clinton and WHO using them.

Oster seemed to be aware that PEPFAR was paying 10x as much as WHO, as she writes "Even at generic drug prices." It is a travesty that she did draw attention to this.

PEPFAR wasn't a humanitarian prog... (read more)

2
SiebeRozendal
6mo
It's pretty much common knowledge about the pharma industry. But here's a decent Wikipedia page: https://en.m.wikipedia.org/wiki/Cost_of_HIV_treatment

How do you know how many people got treatment? I don't see any numbers in this post or its sources.

Herd immunity is a threshold effect. Since the analyses (correctly!) said that few people would receive treatment, it doesn't matter whether the treatment stopped spread, it would have only small effect on the analysis.

5
NickLaing
10mo
Hey Douglas I might be missing something, but the vast majority of people ended up getting HIV treatment, so how was that a correct part of the analysis?

Is there any reason to believe that PEPFAR brought prices down? Why not count Clinton lobbying for price discrimination as economists getting this 100% right? If economists missed the importance of R&D, that's bad, but was it important, or was it just about releasing patents?

1
Douglas Knight
6mo
I think this was wrong. I don't know where I heard the story about Clinton negotiating price discrimination, but, actually, generics already existed in 2001 before either PEPFAR or Clinton started buying. PEPFAR simply refused to use them because it wasn't actually about saving lives. It switched in 2006 because it was embarrassed by Clinton and WHO using them. Oster seemed to be aware that PEPFAR was paying 10x as much as WHO, as she writes "Even at generic drug prices." It is a travesty that she did draw attention to this. PEPFAR wasn't a humanitarian program, but a giveaway to drug companies. It is good that humanitarians stole the money and gave it to public health, but that's no credit to the people who pretended to do charity in the first place. And the cost effectiveness of the project of entering government and stealing money has to be judged by all the people who tried and failed, not just by one project. If this were a real public health project, it would be good to hold it up to tell the other public health projects to be more like it, but it was a sham and telling the other shams to be more like it is unlikely to be effective.
4
SiebeRozendal
10mo
Most drug prices are largely driven by patents, and ARVs were as well.

So if you intuit that we can do better than peer review, I would recommend getting a PhD in economics under a highly-respected supervisor, and learn how to investigate institutions like peer review (against proposed alternatives!) with a level of rigor that satisfies high-prestige economists.

Wow, that's really specific. Are you trying to evoke Robin Hanson? Before following him, ask him if it's a good idea. I think he regrets his path.

1
Michael_Cohen
1y
Robin Hanson didn't occur to me when I wrote it or any of the times I read it! I was just trying to channel what I thought conventional advice would be.

The NYT may be an outlier among papers, but this instance is not an outlier of the NYT approach.

Yeah I've heard elsewhere that NYT is pretty unusual here, would trust them less than other media.

That she is honest is evidence that it was an honest mistake. That she is careful is evidence that it was not.

Another trusted party signing data is mail providers (DKIM), in particular mail sent through Google is signed. Google can't repudiate these signatures, but you have to trust them not to write new history. Matthew Green calls for the opposite: for Google to publish its old private keys to destroy this information.

2
Axel Svensson
1y
Interesting take on the dangers of strong validation. I note that time-stamping the signatures would prevent Google both from writing new history, and from doing what Mr Green wants. I haven't taken the time to consider whether Mr Green's point is valid, but i instinctively hope it isn't because of what it would mean for the value of aiding truth-seeking.

My guess is that this is the June figure for the FTX Future Fund grant commitments. The current figure is $160M as of September 1st. Some of these grants were in installments, especially the multi-year ones, and not all of the money was transferred. This Fund was "longtermist" and I do not see a dollar figure on other FTX charitable giving. This does not include $500M in equity in Anthropic.

Added, weeks later: Or maybe he got it from NYT:

As recently as last month, the umbrella FTX Foundation said it had given away $140 million, of which $90 million went th

... (read more)
0
Greg_Colbourn
1y
Kind of ironic that they were "longtermist" about the world, but not about their own existence!
2
Greg_Colbourn
1y
Thanks, there is also $32M from the regrants tab. But yes, difficult to know the actual total of payouts without word from the staff. Or payouts not subject to clawback without further details on legal proceedings.

Robinhood allowed leverage, but I don't think that had anything to do with the crisis.

Warren Buffett (following Ted Turner) funded the project that is the most impressive example of just throwing money at a problem: buying ex-Soviet nuclear material. Most of the credit should go to Nunn and Lugar, but if we're talking about scalability and what billionaires can do, this should be exhibit A.

Suggestion:

Distinguish or isolate the intro and conclusion about the Nonlinear Library from the main content. 

Ideally, use a different voice (eg, a human recording). A common solution is to insert a chime. Either of those would require splicing audio files. If you want to keep to just splicing text files, maybe there's a way of inserting something to make the TTL pause?

3
Charles He
2y
Amazon Polly, the backend that provides these recordings, lets you use "SSML", basically a trivial annotation of text, that you can easily use to add pauses (as well as emphasis, pitch, volume, etc.). Basically, what you're asking for is probably a 2-3 line pull request. (Nonlinear might be using SSML, if not, it's pretty easy to add it.)

It may be hard to compare art from different periods, but it is direct to compare science and engineering from different periods because the same thing was discovered or invented multiple times.

Knowledge is not a ratchet. Sometimes knowledge is lost. But it is not only catastrophes like burning libraries and riots against scholars. There are Leaden Ages where scientific knowledge is lost century after century, such as Alexandria for about five centuries starting  150AD. Any period of progress is a Golden Age compared to that. Do people know that they ... (read more)