All of John's Comments + Replies
The SENS approach is to remove calcium deposits in arteries at rate faster than calcium deposited. Arteries can tolerate some calcium deposits. Excess calcium deposits cause cardiovascular events like stroke and heart attack. We all have small calcium deposits in our arteries. We're fine because there isn't too much yet.
Everything that works in machine is antagonistic pleiotropy. Car brakes stop car from crashing. But using car brakes wears out (damages) brakes. Machines damage themselves via machines normal operation. Also known as wear and tear. To keep machine functioning forever just need to repair machine at rate faster than damage laid down. Damage is defined as structural changes to the machine that impair machine function. Machine can only tolerate finite amount of structural change. Too much structural change stops machine function leading to death.