12Joined Sep 2022


Arguments for

  • Access to harmful research would be restricted
  • The pace of relevant research would slow (allowing for regulation to catch up)

Arguments against

  • Malevolent actor could publish or retrieve said information elsewhere than arxiv/bioRxiv/medRxiv/participating publisher. Members of the International Gene Synthesis Consortium (IGSC) voluntarily apply screening standards to assess gene sequence orders and customers, and these companies today only represent approximately 80% of global commercial gene synthesis capacity so compulsory filtering, or better coordination of the industry (which stricter self-regulation at this stage may deter) is required.
  • Benevolent actors would be face higher barriers to access useful information

For further investigation

  • Would Industry lead censorship could crowd-out or crowd-in government intervention that could enforce vetting across publishers and in other initiatives? 
  • Would insulating the riskiest dual use publications from exposure to a broader pool of researchers accessing conventional publishers have unintended consequences?


How would vetters, whether a regulatory agency or an independent initiative, screen papers? In the case of DNA synthesis, which does not account for all biosecurity relevant dual use research, a minimalistic approach is for vetters to utilise an encrypted database of riskier sequences of DNA , as proposed by MIT's Prof Kevin Esvelt.  

However, dual use control at the publisher level would presumably not be restricted to DNA synthesis, it would include such things as studies of remote areas at the human-animal boundary.

Next steps

Esvelt is in dialogue with the Nuclear Threat Initiative who are coordinating higher level conversation in this area. If the publishers you mentioned aren't already part of that dialogue, the best next steps may be to connect Nuclear Threat Initiative folks with those academic publishers. But, I don't think that should mean this initiative shouldn't proceed in parallel. I think there is merit in taking some action now in this space because the conversation that the Nuclear Threat Initiative and co are kindling is a slow, multilateral process - screening DNA synthesis orders is not legally required by any national government at this stage.

Time sensitivity

The cost of DNA synthesis is declining and the fixed costs of filtering could grow as fraction of the cost, therefore the viability of a voluntary screening model could its highest right now.


I'm interested in being involved, but don't know that much about academic publishing or technical genomics stuff so probably not a fit to be a (solo) project lead. Do know about management, health policy, public administration, stakeholder engagement, communications etc