Thanks so much for your answers, really interesting to hear the multiple perspectives.  I don't think I'll be giving up on type 1 any time soon since my daughter has the condition and I volunteer with a type 1 advocacy charity (called T1International).  

I think it's great to reflect on how best to use funds though, and I think going for large scale systemic change and advocating for policy change (which we do) is in our case the right thing.  Advocacy impact is non-linear and much harder to measure, but when the wins come, they tend to be big and make positive changes for lots of people.  

I don't want to give up on advocating for health equity for the type 1 population when so many people have to spend so much of their monthly income just to stay alive due to the price of insulin, but I like the idea of thinking about appropriate causes in percentage terms.