I also wonder about this. I'm excited to see where research in the field leads.

Yeah, to be fair, I do think that the broad trend argument is probably the strongest argument for longtermism. Like, it appears that humanity has continuously expanded and grown for the past 12,000 years. If this trend continues, then it makes sense to think that eventually we'll have the technology to start expanding into space.

Ah, thank you!

I'm glad you looked at it!

Thanks!

Yeah, I agree that it's important to get more information than merely "fear of pandemic."

If you haven't already, I'd recommend reading Abi Olvera's series on this. She argues that AI people think about virology completely differently than virology people do. From the perspective she offers, engineered pandemics seem a lot less concerning than the AI community makes them out to be.

The metabolic energy argument makes sense. It's unclear to me whether we should apply any kind of power law though since consciousness seems to be different in nature, as I view it as likely non-physical.

Three things:

1. I don't think we should take the enormous size of the future into account because I don't think we have sufficient knowledge about the future to have any good guesses on how large humanity will become or whether it will create a world that we would approve of. As such, I would measure the value of existential risk reduction much more conservatively, such as the number of humans over the next two hundred years who wouldn't be born.
2. I find the chance of an existential risk from biorisks to be extremely low (I.e. 10^-7). This is because I think that, for a biorisk to be an existential risk, I think that it would have to make the surface of the Earth unlivable for an extended period of time. Otherwise, a significant number of humans will survive and be able to continue civilization. I find this unlikely to occur because, even if this is technically possible, it would be extraordinarily difficult. (That said, I haven't looked into mirror bacteria.)
3. Even among people who are worried about engineered pandemics, virtually none of the are worried about existential risk. As such, if we're basing our view on other people's view, and (1) very few experts are concerned about engineered pandemics (2) very few of those experts are worried about existential risk (3) we have the prior that we should significantly discount fringe views because they're almost always wrong, then we can reasonably get to quite a low risk of engineered pandemics.

I definitely agree with the idea of doing a bit of a numbers game though. If the numbers suggest we should be really focused on biorisks over other concerns, I think it makes sense to allocate a lot of resources towards it.

Thanks for sharing that post. I made this comment on it in case you're curious.

You write:

Generating higher-intensity affective states likely involves greater activation within nociceptive pathways and broader engagement of central processing systems. In both vertebrates and invertebrates, increasing signal strength is associated with recruiting additional processing units and enhanced synaptic transmission, which demand greater energy

This seems plausible to me.

Then, you argue:

Measuring the energetic and computational demands of pain-processing systems across species could help determine whether primitive nervous systems had the capacity to support high-intensity pain.

One problem I find with this is that it seems like it would be very difficult to assess how much "energetic and computational demands" constitutes high-intensity pain.

For instance, let's imagine that, hypothetically, each organism has one part of its nervous system where the amount of energy that runs through it is linearly related to the total amount of pain the organism experience.

If this were the case, we could then measure how much energy corresponds to high-intensity pain in humans. Then, we could find primitive organisms and measure how much energy goes through their neuronal pain region. If it were the same amount as humans for high-intensity pain, then we would know that they also experience high-intensity pain.

Problematically, though, this hypothetical scenario is very different from reality:

1. We don't know how whether energy linearly corresponds to pain.
2. The amount of activation in the human brain doesn't correspond to the amount of pain experienced.
3. We have not mapped out what exact parts of the human brain cause pain and how different patterns of activation correspond to different pain levels.

That said, it seems like this framework may help us to compare pain across simple organisms though. If two organisms are quite similar but one uses much more energy, then, perhaps, it experiences much more pain.