Congratulations on an excellent year of research and thank you for your contributions to this cause area!
To offer a perhaps under-explored research thread in the treatment and mitigation of cluster headaches and migraines, which I haven't seen in pieces from HLI or OPIS, there appears to be moderately high efficacy (for n=18) of a ketogenic diet on reduction in incidence of such headaches:
"Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at l... (read more)
Thank you. I certainly agree that in most occupations (operating large machinery, doing difficult cognitive tasks) and studying, it is not of benefit to feel high on the job. However, I would note important to note that 1) partial opioid agonists have significantly more mild euphoriant properties than full agonists and 2) Kratom, which contains a partial mu-opioid agonist, has traditionally been used in Southeast Asia by field laborers as a ‘labor enhancement’ to enjoy their work more and combat their pain problems (https://www.ncbi.nlm.nih.gov/pmc/article