qfrerichs

Wiki Contributions

Comments

2020 Annual Review from the Happier Lives Institute

Congratulations on an excellent year of research and thank you for your contributions to this cause area! 

To offer a perhaps under-explored  research thread in the treatment and mitigation of cluster headaches and migraines, which I haven't seen in pieces from HLI or OPIS, there appears to be moderately high efficacy (for n=18) of a ketogenic diet on reduction in incidence of such headaches: 

"Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet)" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816269/). 

Keto diets are quite restrictive, require an adaptation period (anywhere from 2 days  - 2 weeks, the above study utilized an 18-day period, https://hvmn.com/blogs/blog/ketosis-how-long-does-it-take-to-get-into-ketosis-and-keto-adapt) and are often not particularly animal wellfare-friendly. 

I'd be interested to explore the cost-effectiveness of an intervention based on using exogenous ketones, especially those derived from plants (somewhere around $1-2 per day? e.g. https://shop.perfectketo.com/products/powdered-mct-oil-from-coconuts-for-keto-and-ketosis, https://rspnutrition.com/products/ketobhb) as an alternative to drug-based treatment of CH. Although research is sparse, it seems probable that exogenous ketones also decrease the adaptation period to a keto diet (ethically important due to the extreme nature of these conditions). There are some reported, rather mild side effects to exogenous ketones (https://perfectketo.com/why-ketones-cause-stomach-pain/), but these seem negligible in the case of treating CH and migraines. 

Using Ibogaine to Create Friendlier Opioids

Thank you. I certainly agree that in most occupations (operating large machinery, doing difficult cognitive tasks) and studying, it is not of benefit to feel high on the job. However, I would note important to note that 1) partial opioid agonists have significantly more mild euphoriant properties than full agonists and 2) Kratom, which contains a partial mu-opioid agonist, has traditionally been used in Southeast Asia by field laborers as a ‘labor enhancement’ to enjoy their work more and combat their pain problems (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657101/). For individuals who spend the majority of their lives in grueling conditions and who appear to be facilitated rather than harmed by the effects of partial agonist opioids, I see more benefit than harm to having a slightly euphoria-inducing agent. For other occupations, this makes less sense.