To extend this recent EA Forum Post, I wanted to share the results of Qualia Research Institute’s research into using tryptamines to abort and prevent cluster headaches. While the quotes and statistics contained here can provide some notion of the pain experienced by cluster headache sufferers, I think it is truly unimaginable. This report contains specific interventions to be pursued in both a philanthropic and for-profit business capacity. While for-profit options are beyond our scope, those interested in supporting philanthropic interventions should consider donating to ClusterBusters (the most important nonprofit dedicated to researching treatments for cluster headaches), or QRI (which does foundational research on ways to reduce intense suffering).
Mission: Instantly and safely abort cluster headaches and treat migraines, the #2 and #10 (respectively) most painful medical conditions according to NHS. Emphasis is placed on chronic cluster headaches, which account for as much as 80% of all clusters and currently lack an effective treatment option.
“Even child birth is 1/10th the pain of a cluster headache, seriously this name needs to change… call it ultra super migraine.” (source)
- A back of the envelope calculation indicates there are roughly 14 thousand people enduring a cluster headache right now.
- 14.2% of US adults 18 or older reported having migraine or severe headache in the previous 3 months in the 2012 NHIS. The overall age-adjusted 3-month prevalence of migraine in females was 19.1% and in males 9.0%, but varied substantially depending on age. (source)
- Current treatments are either ineffective, costly, unsafe, or some combination of the three. The most effective treatments available for cluster headaches include oxygen, which requires the patient to carry an oxygen tank with them at all times, and triptans, which can be used a maximum of three times daily (an issue for chronic sufferers especially) and have side effects from pain to heart attack and stroke. The most effective treatments for migraines include triptans and opioids (which have high addiction potential). Emgality, a more promising treatment for episodic cluster headaches, has recently entered the market, but its long-term risk profile and efficacy have not yet been established.
- Bob Wold founded “Cluster Busters” in 2002 with the explicit purpose of trying to get psychedelics to be prescription medication (see his lecture Treating Cluster Headaches with Psychedelics). He tried over 75 different prescription medications and was at the end of the rope when he found psychedelics could be helpful:
As noted in this Qualia Computing article, the survey surfaced that about 83% of all cluster headaches are experienced by 20% of the sufferers, most of which are classified as ‘chronic’. No existing medication has been approved for use to treat chronic cluster headaches. Vaporizing DMT could be the first such treatment, offering instant relief for cluster headaches as often as they arise in a (potentially large) percentage of sufferers.
“One of the most incredible experiences of my life was when I first aborted a CH [cluster headache] with DMT. That feeling of going from a place of excruciating pain…and feeling the pain fizzle away and die in a matter of seconds” (source)
It is known by a majority of cluster headache sufferers that psychedelics can be highly effective treatments. Due to the legal status of psychedelics, no randomized controlled trial (RCT) has been conducted, but analysis has been done on online forum responses and anonymous surveys, and interviews have been recorded. Evidence from these reports points to a number of important factors: tryptamines (the class of psychedelics which includes compounds like N,N-DMT and psilocybin, the active chemical in ‘magic mushrooms’) seem especially effective, sub-psychoactive and non-psychedelic doses can be therapeutic, and psychedelics can also decrease the frequency of headaches on long time horizons. While smoking/vaporizing is the fastest method of administration available, information from a private correspondence suggests that the FDA may be averse to approving inhalants. Intramuscular administration, utilizing Rick Strassman’s protocol, could be an alternative that would achieve rapid relief without the use of an inhalation device. Since the pain being experienced is so severe, having a faster method of administration is critical.
From the relevant academic literature:
- “The indoleamine hallucinogens, psilocybin, lysergic acid diethylamide, and lysergic acid amide, were comparable to or more efficacious than most conventional medications. These agents were also perceived to shorten/abort a cluster period and bring chronic cluster headache into remission more so than conventional medications.” (source)
- “Also, for DMT, it was suggested that singular or infrequent dosage could have potential long-term beneficial effects on headache disorders: ‘Even a single dose, or perhaps a couple, can be a lifelong benefit.’” (source)
- “Of interest, an open-label study found that similar compounds (2-bromo-LSD) without psychedelic effect were promising for this purpose” (source)
From online surveys:
- A survey of members of online cluster headache forums revealed that 68% of respondents who used tryptamines had a 4 or 5 out of 5 relief. 5 indicates “completely eliminated the cluster headaches”.
- This survey again suggests that the main barrier to use is lack of access and hallucinogenic effects. As we found in an interview with an anonymous sufferer (see below), hallucinogenic effects may be avoidable.
Difficulty getting. 0 – Extremely easy to acquire, 5 – Nearly impossible to acquire
Legal risk. 0 – Not concerned at all, 5 – Extremely concerned
Side effects. 0 – Not concerned at all, 5 – Extremely concerned
From interviews with cluster headache sufferers who have tried N,N-DMT:
- “If I’m starting to experience a CH and I vaporize as little as 3mgs [of DMT, sub psychoactive] I feel the pain subside almost completely within 3 to 5 seconds, and it doesn’t come back for a few days.” – (full document; also: another interview with an anonymous cluster headache sufferer)
III. Philanthropic Opportunities:
Due to the Schedule I status of psychedelics in the United States, pursuing this intervention in the US will not be feasible for a number of years (see Section IV for more information on pursuing FDA approval for DMT for cluster headaches/migraines).
A possible solution would be to create an online education campaign publicizing the results of this report to cluster headache sufferers, designated as ‘information-only’, and pursuing the use of psychedelics to treat cluster headaches and migraines in countries where tryptamines are legal, including Brazil, Jamaica and the Netherlands. In addition, given the gravity of the disorder, it could be cost-effective to fly patients to such countries for months at a time.
While we believe that traditional metrics such as the QALY do not accurately capture the suffering caused by a cluster headache (see upcoming post on the true pain/pleasure scale), a rough QALY calculation would be as follows (focusing on chronic cluster headache sufferers rather than average, since they compromise up to 83% of total headaches):
- Facebook AD campaign:
- An estimated 370,000 Americans suffer from cluster headaches, 68% of whom are on Facebook (=251,000). About 15% of these suffer from chronic cluster headaches (=37,740). According to Sprout Social, the average estimated cost per click of an ad campaign is $1.72. Assuming 1/10 who click are cluster headache sufferers, to reach all chronic sufferers would take (ballpark) $650,000.
- Assuming about 30% of those who view the ad will pursue the treatment (rough estimate-those who put 2 or less on survey results for questions of legality, difficulty to acquire etc.) and that in 68% of cases it cured or nearly cured their clusters (based on survey results), then the resulting increase in QALYs would be (37,740 people * 0.3 * 0.68) * [0.760 (QALY coefficient) * 1 QALY – ( -0.429 (QALY coefficient)* (0.47QALY)) ] = $650,000/7, 404QALY = $87.70 per QALY.
- These ads could also be targeted to users in countries where psilocybin and DMTare legal for use recreationally, increasing conversion rate. Further targeting could be done on Facebook groups (and other social media groups) which are associated with cluster headache treatment.
IV. For-Profit Opportunities:
The recent emergence of psychedelics in for-profit business settings also affords the opportunity for entrepreneurs to seek legal rescheduling of N,N-DMT in the US for the purpose of treating cluster headaches and/or migraines. Below is an outline of the process of navigating the FDA IND process, which could result in a change in legal status:
‘Orphan disease’ status:
There are two main classifications of cluster headaches, chronic and episodic. Episodic cluster headaches are characterized by periods of headaches (up to 8 times per day) of a week to a full year, which remit for periods from a month up to a year. Chronic cluster headaches, on the other hand, either last for longer than a year or have remittance periods of less than a month. A meta-analysis from the NIH estimates that cluster headaches affect 124/100,000 in the U.S., meaning an estimated 370,000 people suffer from cluster headaches a year. Of these, about 15%, or 60,000, suffer from chronic cluster headaches.
The FDA grants ‘orphan disease’ status to diseases which affect fewer than 200,000 persons in the U.S per year, and offers incentives to those pursuing treatments through the FDA’s IND process for such diseases, such as longer periods of exclusivity (monopoly on drug manufacture and sale) for the treatment after approval.
- The global market for migraine drugs (which encompasses cluster headache drugs) in 2017 was $1.7 billion.
- Healthcare and lost productivity costs associated with migraine are estimated to be as high as $36 billion annually in the U.S. Current estimates of cluster headaches’ annual cost in the U.S. is ~$3.5 billion.
- Share of market
- EDIT: A reader pointed out that my initial cost-effectiveness analysis linked a source for 1mg of N,N-DMT priced at ~$100, and my fermi estimate indicated that 1g of N,N-DMT priced at that rate, which significantly impacts the corresponding analysis. Another Sigma Aldrich quote of the price was ~$20/mg. I furthermore have significant uncertainty around up front cost of investment to bring N,N-DMT through Phase 1-3 clinical trials (based on estimates from private correspondence, the figure is in the $100M range) and the economies of scale which might result in drastically different price points for the substance. Further uncertainty comes from differences in regulation and cost of approval in other jurisdictions, particularly Canada and EU nations. For nations (such as Brazil) where N,N-DMT in the form of ayahuasca is fully legal, the cost may be far lower, but is very difficult to accurately estimate. For this post I will continue to quote the ~$20/mg figure from Sigma Aldrich, but given the at least 5X difference in price/dose based on sourcing country/company, I have low confidence in the quality and usefulness of the estimate.
- EDIT #2: Since the original posting, two large (public, private respectively) pharmaceutical companies, MindMed (https://mindmed.co/news/press-release/phase-2-clinical-trial-of-lsd-for-suicide-headaches-begins-treating-patients/) and BrightMindsBio (https://brightmindsbio.com/pain/, apparently partially inspired by this post!) have begun pursuing clinical trials of LSD and tryptamine-like agents for treating cluster headaches. Since these treatments can end a full cycle of cluster headaches rather than aborting a single headache, their cost-effectiveness may be higher, but I do not have the requisite information from these companies to evaluate the figures. I would still contend that, given the extreme nature of the pain caused by CH, an 'epipen-like' way to abort a headache at sub-hallucinogenic doses still seem ethically important and worthy of further study and examination. A Canadian-based pharmaceutical company has also begun developing GMP-grade N,N-DMT (https://www.baystreet.ca/articles/stockstowatch/62556/Entheon-Biomedical-Announces-DMT-Drug-Supply-Agreement-with-Psygen-Labs)
- 5 years after launch (with FDA approval, with a 5-year monopoly) – serving 20% of cluster headache sufferers (35,000 total in the US - rough estimate based on lifetime prevalence)
- Platform’s average annual revenue per patient (with 20% markup):
- Cost of DMT Vape Pen – $20
- 1mg of DMT cost is about $18, leading to ~$55/dose (anecdotal information indicates 3mg is sufficient). Compare to triptans, at ~$115 per 9 doses.
- There is significant variance in frequency of cluster headaches: estimates range from [$22 + $22/mg*3g/dose*30 doses/month *3 months = $5962/patient/year, $22 + $22/mg*3mg/dose*120 doses/month*12 months = $95,062/patient/year]. 10-15% of patients have chronic cluster headaches (https://en.wikipedia.org/wiki/Cluster_headache).
- Annual revenue estimate (10% chronic, 90% low-range episodic, 5 years after launch): $104M/year
- The 5-year (or more, if ‘orphan disease’ status is gained) monopoly provided by the FDA would allow for further R&D, and as-yet undetermined projects. Some promising directions:
- FDA on track to approve MDMA therapy in 2021, psilocybin therapy in 2022
- FDA approval will catalyze a large increase in demand for psychedelic services
- There is sufficient evidence to attempt bringing DMT for headaches through the FDA process as it becomes increasingly open to psychedelic interventions
- A “psychedelic renaissance” is underway: funding for psychedelic research has skyrocketed, and multiple psychedelic decriminalization initiatives (1, 2) have recently passed. Riding the current wave of activist and public support is advantageous to our efforts.
- More time to build relationship with the FDA (important for seeking DMT clearance)
- More time to build relationships with organizations currently seeking FDA approval for therapeutic uses of psychedelics (MAPS & Compass Pathways)
- Taking on the FDA IND process can be challenging and high risk from an investment standpoint. The average cost of successfully completing Phase 1-3 trials (after which the drug can be rescheduled and approved for medical use) is $100m, requires about 9-11 years and has a 6.7% success rate (private correspondence).
- The Multidisciplinary Association for Psychedelic Studies (MAPS) has recently raised $26.7M for Phase 3 MDMA trials alone. Total, MAPS has spent in the ballpark of $30M. If Phase 3 trials demonstrate statistically-significant results, MDMA could be selectively rescheduled for use in therapeutic settings, but would require subsequent Phase 4 trials.
- The FDA is risk-averse and has incurred backlash from their last notable rescheduling of fentanyl in 1985. Convincing the FDA to pursue rescheduling for treatment of a relatively rare disease with other available medications will likely be difficult.
- The success or failure of MAPS in receiving approval for MDMA will be crucial for defining the regulatory landscape for other psychedelics. Should they fail, bringing another similar substance through the process may prove much more difficult.
- As discussed in Section I, most available migraine and cluster headache drugs are ineffective, expensive, and/or have heavy risk profiles. Emgality, a new migraine drug approved last month, has received FDA ‘breakthrough therapy’ status for its ability to decrease the frequency of episodic cluster headaches and has shown promise as a palliative for migraines as well. Emgality has not been approved for use in treating chronic cluster headaches, however, and does not achieve the same rapidity of administration as the DMT vape pen (see Section III). Thus, our solution is still critical for relieving symptoms instantly, and maintains the advantage of being eligible to treat chronic cluster headaches, an ‘orphan disease’.
- We would design studies to fulfill the three-step FDA drug review process:
- Phase 1 studies (typically involve 20 to 80 people).
- Phase 2 studies (typically involve a few dozen to about 300 people).
- Phase 3 studies (typically involve several hundred to about 3,000 people).
Use of Funds
- Expenses for research and operations staff
- Analysis consultants
- Researchers with clinical experience
- Legal counsel (paperwork)
- Phase 1 FDA trial (our connections to expertise in the field would reduce the cost compared to average Phase 1 trials)
Data on Cost of Trials
The following information is from the MDMA/PTSD Trials led by MAPS. However, the treatment for PTSD involves: multiple therapy sessions and an MDMA-trained psychotherapist. Therapy sessions also last 6-8 hours. Presumably, some of these costs would not apply to a DMT/CH trial, so we expect trials for DMT/CH to be cheaper than the MDMA/PTSD Trials.
However, cluster headaches are not well suited to the therapeutic environment that is used to treat mental health conditions (they arise unpredictably, and require instant relief). This means there are likely significant cost-saving opportunities in the experimental design protocol.
Summary of costs for MAPS IND Process:
 Assume a world population of 7.7 billion people, and 53 out of 100,000 yearly prevalence suffering from this. Going by public health records, we see that the average number of cluster headache attacks that a sufferer experiences is about 30 a year (with a huge variance, where some people get only about 5 a year and some get them multiple times a day). Attacks last on average 1 hour (but range from 20 minutes to 3 hours). Hence, the number of people currently experiencing a CH is: 0.00053*7,700,000,000*(30/(24*365)) = 13,976.03 ~= 14 thousand
 According to survey
 For chronic sufferers, an average of between 1-8 CH per day, 1-4 hours per CH, for ~0.47 years/year having CH