All of turchin's Comments + Replies

Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

To collect all that information we need superintelligent AI, and actually we don't need all vibrations, but only the most relevant pieces of data - the data which is capable to predict human behaviour. Such data could be collected from texts, photos, DNA and historical simulations - but it is better to invest in personal life-logging to increase ones chances to be resurrected. 

1JeffreyK10d
Can you point me to more writing on this and tell me the history of it.
Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

I am serious about resurrection of the dead, there are several ways, including running the simulation of the  whole history of mankind and filling the knowledge gaps with random noise which, thanks to Everett, will be correct in one of the branches. I explained this idea in longer article: You Only Live Twice: A Computer Simulation of the Past Could be Used for Technological Resurrection

Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

I need to clarify my views: I want to save humans first, and after that save all animals, from closest to humans to more remote. By "saving" I mean resurrection of the dead, of course. I am pro resurrection of mammoth and I am for cryonics for pets.  Such framework will eventually save everyone, so in infinity it converges with other approaches to saving animals.  

But "saving humans first" gives us a leverage, because we will have more powerful civilisation which will have higher capacity to do more good. If humans will extinct now, animals will ... (read more)

7Harrison Durland11d
I’m afraid you’ve totally lost me at this point. Saving mammoths?? Why?? And are you seriously suggesting that we can resurrect dead people whose brains have completely decayed? What? And what is this about saving humans first? No, we don’t have to save every human first, we theoretically only need to save enough so that the process of (whatever you’re trying to accomplish?) can continue. If we are strictly welfare-maximizing without arbitrary speciesism, it may mean prioritizing saving some of the existing animals over every human currently (although this may be unlikely). To be clear, I certainly understand that you aren’t saying you only care about saving your own life, but the post gives off those kinds of vibes nonetheless.
Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

The transition from "good" to "wellbeing" seems rather innocent, but it opens the way to rather popular line of reasoning: that we should care only about the number of happy observer-moments, without caring whose are these moments. Extrapolating, we stop caring about real humans, but start caring about possible animals. In other words, it opens the way to pure utilitarian-open-individualist bonanza, where value of human life and individuality are lost and badness of death is ignored.  The last point is most important for me, as I view irreversible mor... (read more)

8Harrison Durland12d
To be totally honest, this really gives off vibes of "I personally don't want to die and I therefore don't like moral reasoning that even entertains the idea that humans (me) may not be the only thing we should care about." Gee, what a terrible world it might be if we "start caring about possible animals"! Of course, that's probably not what you're actually/consciously arguing, but the vibes are still there. It particularly feels like motivated reasoning when you gesture to abstract, weakly-defined concepts like the "value of human life and individuality" and imply they should supersede concepts like wellbeing, which, when properly defined and when approaching questions from a utilitarian framework, should arguably subsume everything morally relevant. You seem to dispute the (fundamental concept? application?) of utilitarianism for a variety of reasons—some of which (e.g., your very first example regarding the fog of distance) I see as reflecting a remarkably shallow/motivated (mis)understanding of utilitarianism, to be honest. (For example, the fog case seems to not understand that utilitarian decision-making/analysis is compatible with decision-making under uncertainty.) If you'd like to make a more compelling criticism that stems from rebuffing utilitarianism, I would strongly learning more about the framework from people who at least decently understand and promote/use the concept, such as here: https://www.utilitarianism.net/objections-to-utilitarianism#general-ways-of-responding-to-objections-to-utiliarianism [https://www.utilitarianism.net/objections-to-utilitarianism#general-ways-of-responding-to-objections-to-utiliarianism]
Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

The problem with (1) is that here it is assumed that fuzzy set of well-being has a subset of "real goodness" inside it, but we just don't know how to define it correctly. But it could be the real goodness is outside well-being. In my view, reaching radical life extension  and death-reversal is more important than well-being, if it is understood as comfortable healthy life. 

The fact that  an organisation is doing good assumes that some concept of good exists in it. And we can't do good effectively without measuring it, which requires even str... (read more)

1Harrison Durland13d
In short, I don't find your arguments persuasive, and I think they're derived from some errors such as equivocation, weird definitions, etc. First of all, I don't understand the conflict here—why would you want life extension/death reversal if not to improve wellbeing? Wellbeing is almost definitionally what makes life worth living; I think you simply may not be translating or understanding "wellbeing" correctly. Furthermore, you don't seem to offer any justification for that view: what could plausibly make life extension and death-reversal more valuable than wellbeing (given that wellbeing is still what determines the quality of life of the extended lives). You can assert things as much as you'd like, but that doesn't justify the claims. Someone does not need to objectively, 100% confidently "know" what is "good" nor how to measure it if various rough principles, intuition, and partial analysis suffices. Maybe saving people from being tortured or killed isn't good—I can't mathematically or psychologically prove to you why it is good—but that doesn't mean I should be indifferent about pressing a button which prevents 100 people from being tortured until I can figure out how to rigorously prove what is "good." This almost feels like a non-sequitur that fails to explicitly make a point, but my impression is that it's saying "it's inconsistent/contradictory to think that we can decide what organizations should do but not be able to align AI." 1) This and the following paragraph still don't address my second point from my previous comment, and so you can't say "well, I know that (2) is a problem, but I'm talking about the inconsistency"—a sufficient justification for the inconsistency is (2) all by itself; 2) The reason we can do this with organizations more comfortably is that mistakes are far more corrigible, whereas with sufficiently powerful AI systems, screwing up the alignment/goals may be the last meaningful mistake we ever make. I very slightly agree with th
Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

Two things I am speaking about are: 

(1) what is terminal moral value (good)  and 

(2) how we can increase it.

EA have some understanding what are 1 and 2, like 1 = wellbeing and 2 = donations to effective charities.

But if we ask AI safety researcher, he can't point on what should be the final goal of a friendly AI. Maximum what he can say is that future superintelligence will solve this task. Any attempt to define "good" will suffer from our incomplete understanding.

EA works  both on AI safety, where good is undefined, and on non-AI-relat... (read more)

1Harrison Durland13d
In that case, I think there are some issues with equivocation and/or oversimplification in this comparison: 1. EAs don’t “know what is good” in specific terms like “how do we rigorously define and measure the concept of ‘goodness’”; well-being is a broad metric which we tend to use because people understand each other, which is made easier by the fact that humans tend to have roughly similar goals and constraints. (There are other things to say here, but the more important point is next.) 2. One of the major problems we face with AI safety is that even if we knew how to objectively define and measure good we aren’t sure how to encode that into a machine and ensure it does what we actually want it to do (as opposed to exploiting loopholes or other forms of reward hacking). So the following statement doesn’t seem to be a valid criticism/contradiction:
Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

When I tell people that have reminded a driver to look at a pedestrian ahead and probably saved that pedestrian, people generally react negatively, saying something like the driver will see the pedestrian anyway eventually, but my crazy reaction could have distracted him. 

Also, once I almost pull a girl back to safety from a street where a SUV was ready to hit her - and she does't not even call my on my birthdays! So helping neighbours doesn't give  status in my experience.

Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

Actually, I wanted to say something like this: "here is a list of half-baked critiques, let me know which ones intrigue you and I will elaborate on them", but removed my introduction, as I think that it will be too personal. Below is what was  cut:

"I consider myself an effective altruist: I strive for the benefit of the greatest number of people. I spent around 15 years of my life on topics which I consider EA.

 At the same time, there is some difference in my understanding of EA from the “mainstream” EA: My view is that the real good is preventio... (read more)

Effective altruism is similar to the AI alignment problem and suffers from the same difficulties [Criticism and Red Teaming Contest entry]

If in  Homograd everyone will be absolute copies of each other, the city will have much less moral value for me.

If in Homograd there will be only two exact copies of two people, and all other people will be different, if would mean for me that its real population is N-1, so I will chose to nuke Homograd.

But! I don't judge diversity here as aesthetic, but only as a chance that there will be more or less exact copies.

My list of effective altruism ideas that seem to be underexplored

I think that there is way to calculate relative probabilities even in infinite case and it will converge to 1:. For example, there is an article "The watchers of multiverse" which suggest a plausible way to do so. 
 

2Frank_R1mo
Thank you for the link to the paper. I find Alexander Vilenkins theoretical work very interesting.
My list of effective altruism ideas that seem to be underexplored

1.The identity problems is known to be difficult, but here I assume that continuity of consciousness is not needed for it. Only informational identity is enough.

2. The difference between quantum - or big world- immortality is that we can select which minds to create and exclude N+1 moments which are damages or suffering. 

1Frank_R1mo
Let us assume that a typical large but finite volume containsnhappy simulations of you andn⋅10−100suffering copies of you, maybe Boltzmann brains or simulations made by a malevolent agent. If the universe is infinite, you have infinitely many happy and infinitely suffering copies of you and it is hard how to interpret this result.
My current thoughts on the risks from SETI

If aliens need only powerful computers to produce interesting qualia, this will be no different from other large scale projects, and boils down to some Dyson spheres-like objects. But we don't know how qualia appear. 

Also, a whole human industry of tourism is only producing pleasant qualia. Extrapolating, aliens will have mega-tourism: almost pristine universe, where some beings interact with nature in very intimate ways. Now it becomes similar to some observations of UFOs.

My list of effective altruism ideas that seem to be underexplored

I support animal resurrection too, but only after all humans will be resurrected. Again starting from most complex and close to human animals, like pets, primates. Also, it seems that some animals will be resurrected before humans, like mammoth, nematodes and some pets.

When I speak about human preferences, I mean current preferences: people do not want to die now and many prefer that they will be resuscitated if no damage.

My list of effective altruism ideas that seem to be underexplored

Thanks, I do a lot of lifelogging, but didn't know about this app.

My list of effective altruism ideas that seem to be underexplored

If we simulate all possible universes, we can do it. It is enormous computational task, but it can be done via acausal cooperation between different branches of multiverse, where each of them simulate only one history.

2Frank_R1mo
I see two problems with your proposal: 1. It is not clear if a simulation of you in a patch of spacetime that is not causally connected to our part of the universe is the same as you. If you care only about the total amount of happy experiences, this would not matter, but if you care about personal identity, it becomes a non-trivial problem. 2. You probably assume that the multiverse is infinite. If this is the case, you can simply assume that for every copy of you that lives for N years another copy of you that lives for N+1 years appears somewhere by chance. In that case there would be no need to perform any action. I am not against your ideas, but I am afraid that there are many conceptual and physical problems that have to solved before. What is even worse is that there is no universally accepted method how to resolve this issues. So a lot of further research is necessary.
My list of effective altruism ideas that seem to be underexplored

Humans have strong preference not die, and they -many of them -would like to be resurrected if it will be possible and will be done with high quality. I am supporter of the preferential utilitarianism, so I care not only of the number of happy of observer-moments, but also about what people really want.

Anyway, resurrecting  is a limited task: only 100 billion people ever lived, and resurrecting them all will not preclude as of creating of trillions of trillions new happy people.

Also, mortal being can't be really happy. So new people need to be immortal or they will suffer of existential dread.

1Konstantin Pilz1mo
Interesting, thanks! Though I don't see why you'd only ressurect humans since animals seem to have the preference to survive as well. Anyways, I think preferences are often misleading and are not a good proxy for what would really be fulfilling. To me it also seems odd to say that a preference remains even if the person is no longer existing. Do you believe in souls or how do you make that work? (Sorry for the naivety, happy about any recs on the topic)
My list of effective altruism ideas that seem to be underexplored

If we start space colonisation, we may not be able to change goal-system of the spaceships that we will send to stars, as they will move away with near-light speed. So we need to specify what we will do with the universe before starting the space colonisation: either we will spend all resources to build as many simulations with happy minds as possible – or we will reorganise matter in the ways with will help to survive the end of the universe, e.g. building Tipler's Omega point or building worm hole into another universe.

---

Very high precision of brain det... (read more)

1Frank_R1mo
Thank you for your answers. With better brain preservation and a more detailed understanding of the mind it may be possible to resurrect recently deceased persons. I am more skeptical about the possibility to resurrect a peasant from the middle ages by simulating the universe backwards, but of course these are different issues.
Geoengineering to reduce global catastrophic risk?

Yes, I come here to say that building dams is a type of geoengineering, but it is net positive despite occasional catastrophic failures.

The future of nuclear war

Thanks for correction, it is tons in that case, as he speaks about small yield weapons. 

Arguments for Why Preventing Human Extinction is Wrong

Yes. Also l-risks should be added in the list of letter-risks: the risks that all life will go extinct, if humans continue to do what they do in ecology - and it is covered in section 5 of the post.

Arguments for Why Preventing Human Extinction is Wrong

I don't endorse it, but a-risks could be added: the risks that future human space colonistion will kill or prevent appearance of alien civilizations.

Seems like a generalization of d-risks.

Risks from Autonomous Weapon Systems and Military AI

I always don't know if it is appropriate to put links on own articles in the comments. Will it be seen as  just self-advertising? Or they may contribute to discussion?

I looked at these problems in two articles:

Could slaughterbots wipe out humanity? Assessment of the global catastrophic risk posed by autonomous weapons 

and

Military AI as a Convergent Goal of Self-Improving AI

Release of Existential Risk Research database

Thanks! BTW, I found that some my x-risks related articles are included while other  are not. I don't think that it is because not-included articles are more off-topic, so your search algorithm may fail to find them.

Examples of my published relevant articles which were not included: 

The Global Catastrophic Risks Connected with Possibility of Finding Alien AI During SETI

Islands as refuges for surviving global catastrophes

Surviving global risks through the preservation of humanity's data on the Moon

Aquatic refuges for surviving a global catastrophe... (read more)

2rumtin2mo
Hi Alexey - it's strange you can't see them, because all of those are already in the database. Searching directly for them is the easiest way as the way the author names are listed is a bit inconsistent (e.g. sometimes it's Alexey Turchin and other times Turchin A.)
[Paper] Surviving global risks through the preservation of humanity's data on the Moon

If they advance enough to reconstruct us, then most of bad enslavement ways are likely not interesting to them. For example, we no try to reconstruct mammoths in order to improve climate in Siberia, but not for hunting or meet.

Thoughts on short timelines

Yes, it is clear. My question was: "Do we have any specific difference in mind about AI strategies for 1 per cent in 10 years vs. 10 per cent in 10 years cases?" If we going to ignore the risk in both cases, there is no difference is it 1 per cent or 10 per cent.

I don't know any short-term publically available strategy for the 10 years case, no matter what is the probability.

Thoughts on short timelines

What is the actionable difference between "1-2 per cent" and "10 per cent" predictions? If we knew that an asteroid is coming to Earth and it will hit the Earth with one of these probabilities, how our attempts to diverge it would depend on the probability of the impact?

Should we ignore 1 per cent probability, but go all-in in preventing 10 per cent probability?

If there is no difference in actions, the difference in probability estimates is rather meaningless.

4Jeff Kaufman4y
You can extend your argument to even smaller probabilities: how much effort should go into this if we think the chance is 0.1%? 0.01? Or in the other direction, 50%, 90%, etc. In extremes it's very clear that this should affect how much focus we put into averting it, and I don't think there's anything special about 1% vs 10% in this regard. Another way of thinking about it is that AI is not the only existential risk. If your estimate for AI is 1% in the next ten years but pandemics is 10%, vs 10% for AI and 1% for pandemics, then that should also affect where you think people should focus.
The Map of Impact Risks and Asteroid Defense

Thanks - just saw this comment now. Not really miss the idea, but not decoded include it here.

Curing past sufferings and preventing s-risks via indexical uncertainty

If the connection between observer-moments is not regarded as important (as I understand, this is your point of view: there is no identity that chains observer-moments in timelines) - than the creation of happy observer-moments is also a way to dilute past sufferings.

In other words, the creation of infinitely many happy observer-moments in the future makes the probability that a person finds himself into a suffering observer-moment infinitely small.

I addressed the problem of the simulation of evil AIs in the "Message to any future AI" text, whi... (read more)

Curing past sufferings and preventing s-risks via indexical uncertainty

See patches in comments below: there are ways to do the trick not increasing the total number of suffering observer-moments.

Curing past sufferings and preventing s-risks via indexical uncertainty

It will also increase the number of happy observer-moments globally, because of the happiness of being saved from agony plus lowering the number of Evil AIs, as they will know they will lose and will be punished.

Curing past sufferings and preventing s-risks via indexical uncertainty

I just find the way how the whole trick will increase total welfare in the multiverse, copied from the comment below:

No copies of suffering observer-moments will be created - only the next moment after suffering will be simulated and diluted, and this will be obviously the happiest moment for someone in agony - to feel that the pain disappeared and to know that he is saved from hell.

It will be like an angel, who comes to a cancer patient and tells him: your disease was just completely cured. If one ever got a negative result for cancer test, he may know... (read more)

1kbog4y
There is no reason to prefer that over simply creating people with happy lives. You can always simulate someone who believes that they have just been saved from suffering if that constitutes the best life. The relation to some historical person who suffered is irrelevant and inefficient. Deterring unfriendly AI is another matter. There are so many possible goal functions that can be used to describe possible unfriendly AIs that a general strategy for deterring them doesn't make sense. At least not without a lot of theoretical groundwork that is presently lacking.
Curing past sufferings and preventing s-risks via indexical uncertainty

This is because you use not-copy-friendly theory of personal identity, which is reasonable but has other consequences.

I patched the second problem in comments above - only the next moment after suffering will be simulated and diluted, and this will be obviously the happiest moment for someone in agony - to feel that the pain disappeared and to know that he is saved from hell.

It will be like an angel, who comes to a cancer patient and tells him: your disease was just completely cured. If one ever got a negative result for cancer test, he may know this feel... (read more)

Curing past sufferings and preventing s-risks via indexical uncertainty

See my patch to the argument in the comment to Lukas: we can simulate those moments which are not in intense pain, but still are very close to the initial suffering-observer moment, so they could be regarded its continuation.

Curing past sufferings and preventing s-risks via indexical uncertainty

It is an algorithmic trick only if personal identity is strongly connected to exact this physical brain. But in the text, it is assumed that identity is not brain-connected, without any discussion. However, it doesn't mean that I completely endorse this "copy-friendly" theory of identity.

2kbog4y
Identity is irrelevant if you evaluate total or average welfare through a standard utilitarian model.
Curing past sufferings and preventing s-risks via indexical uncertainty

I could see three possible problems:

The method will create new suffering moments, and even may be those suffering moments, which will not exist otherwise. But there is a patch for it: see my comment above to Lukas.

The second possible problem is that the universe will be tiled with past simulations which try to resurrect any ant ever lived on Earth – and thus there will be an opportunity cost, as many other good things could be done. This could be patched by what could be called "cheating death in Damascus" approach where some timelines choose no... (read more)

Curing past sufferings and preventing s-risks via indexical uncertainty

Reading your comment I come to the following patch of my argument: benevolent AI starts not from S(t), but immediately from many copies of those S(t+1) which have much less intense sufferings, but still have enough similarity with S(t) to be regarded as its next moment of experience. Not S(t) will be diluted, but the next moments of the S(t). This solves the need to create many S(t)-moments which seems morally wrong and computationally intensive.

My plan is that FAI can't decrease the number of suffering moments, but the plan is to create an immediate way o... (read more)

1Lukas_Finnveden4y
I remain unconvinced, probably because I mostly care about observer-moments, and don't really care what happens to individuals independently of this. You could plausibly construct some ethical theory that cares about identity in particular way such that this works, but I can't quite see how it would look, yet. You might want to make those ethical intuitions as concrete as you can, and put them under 'Assumptions'.
Principia Qualia: blueprint for a new cause area, consciousness research with an eye toward ethics and x-risk

What if AI exploring moral uncertainty finds that there is provably no correct moral theory or right moral facts? It that case, there is no moral uncertainty between moral theories, as they are all false. Could it escape this obstacle just by aggregating human's opinion about possible situations?

1kbog4y
In that case it would be exploring traditional metaethics, not moral uncertainty. But if moral uncertainty is used as a solution then we just bake in some high level criteria for the appropriateness of a moral theory, and the credences will necessarily sum to 1. This is little different from baking in coherent extrapolated volition. In either case the agent is directly motivated to do whatever it is that satisfies our designated criteria, and it will still want to do it regardless of what it thinks about moral realism. Those criteria might be very vague and philosophical, or they might be very specific and physical (like 'would a simulation of Bertrand Russell say "a-ha, that's a good theory"?'), but either way they will be specified.
Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

One more problem with the idea that I should consult my friends first before publishing a text is a "friend' bias": people who are my friends tend to react more positively on the same text than those who are not friends. I personally had a situation when my friends told me that my text is good and non-info-hazardous, but when I presented it to people who didn't know me, their reaction was opposite.

Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

Sometimes, when I work on a complex problem, I feel as if I become one of the best specialists in it. Surely, I know three other people who are able to understand my logic, but one of them is dead, another is not replying on my emails and the third one has his own vision, affected by some obvious flaw. So none of them could give me correct advice about the informational hazard.

Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

It would be great to have some kind of a committee for info-hazards assessment, like a group of trusted people who will a) will take responsibility to decide whether the idea should be published or not b) will read all incoming suggestions in timely manner с) their contacts (but may be not all the personalities) will be publicly known.

5Jan_Kulveit4y
I believe this is something worth exploring. My model is that while most active people thinking about x-risks have some sort of social network links so they can ask others, there may be a long tail of people thinking in isolation, who may at some point just post something dangerous on LessWrong. (Also there is a problem of incentives, which are often strongly in favor of publishing. You don't get much credit for not publishing dangerous ideas, if you are not allready part of some established group.)
Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

It was in fact a link on the article about how to kill everybody using multiple simultaneous pandemics - this idea may be regarded by someone as an informational hazard, but it was already suggested by some terrorists from Voluntary Human extinction movement. I also discussed with some biologists and other x-risks researchers and we concluded that it is not an infohazard. I can send you a draft.

Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

I've not had the best luck reaching out to talk to people about my ideas. I expect that the majority of new ideas will come from people not heavily inside the group and thus less influenced by group think. So you might want to think of solutions that take that into consideration.

Yes, I met the same problem. The best way to find people who are interested and are able to understand the specific problem is to publish the idea openly in a place like this forum, but in that situation, hypothtical bad people also will be able to read the idea.

Also, info-haza... (read more)

Informational hazards and the cost-effectiveness of open discussion of catastrophic risks

That is absolutely right, and I am always discussing ideas with friends and advanced specialist before discussing them publicly. But doing this, I discovered two obstacles:

1) If the idea is really simple, it is likely not new, but in case of a complex idea not much people are able to properly evaluate it. Maybe if Bostrom will spend a few days analysing it, he will say "yes" or "no", but typically best thinkers are very busy with their own deadlines, and will not have time to evaluate the ideas of random people. So you are limited to yo... (read more)

Expected cost per life saved of the TAME trial

That is why I think that we should divide discussion in two lines: One is the potential impact of simple interventions in life extension, which are many, and another is, is it possible that metformin will be such simple intervention.

In case of metformin, there is a tendency to prescribe it to the larger share of the population, as a first line drug of diabetes 2, but I think that its safety should be personalized by some genetic tests and bloodwork for vitamin deficiency.

Around 30 mln people in US or 10 per cent of the population already have diabetes 2 (h... (read more)

Expected cost per life saved of the TAME trial

Thanks for this detailed analysis. I think that the main difference in our estimations is the number of adopters, which is 1.3 percent in your average case. In my estimation, it was almost a half of the world population.

This difference highlights the important problem: how to make really good life-extending intervention widely adopted. This question is related not only to metformin, but for any other interventions, including now known interventions such as sport, healthy diet and quitting smoking, which all depends on a person's will.

Taking a pill will r... (read more)

0Lila4y
Metformin isn't a supplement though. It's unlikely it would ever get approved as a supplement or OTC, especially given that it has serious side effects.
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