The burden of disease (also called disease burden and global burden of disease) is the total impact of disease in a population.


The concept of burden of disease originates in a study commissioned by the World Bank in 1990 and undertaken in collaboration with Harvard University and the World Health Organization. The study, published in the World Bank's 1993 World Development Report and known as the first Global Burden of Disease study (GBD 1990), was a comprehensive effort to quantify the healthy life years lost globally not only from premature death but also from nonfatal medical conditions (World Bank 1993). To measure this loss, GBD 1990 introduced the Disability-Adjusted Life Year (DALY), a metric which has since become common in health impact assessment and informed policy-making. GBD 1990 had considerable influence, both in stimulating other studies focused on various subpopulations, and in contributing to the setting of global health priorities (Mathers 2017).

Between 1998 and 2004, further GBD studies were published by the World Health Organization. Since 2010, GBD studies are carried out by the Institute for Health Metrics and Evaluation (IHME). The most recent study was conducted in 2019....

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