Nice! I've been doing annual reviews loosely following Alex Vermeer's guide for the past few years, and my sense is that they've been extremely valuable.

Thanks for writing this! The "how to make writing more engaging" section seems useful to me, and so does the general pointer to at least consider putting more effort into being engaging with public writing.

I agree with the general sentiment in some of the other comments that's along the lines of "actually sometimes a relatively dry style makes sense".  I personally have pretty mixed feelings about the "Lesswrong style" (as a reader and a writer).

(For what it's worth, I didn't really have a problem with the previous title. I probably would have hesitated before using that title myself, but I often feel like I'm too conservative about these things)

Oh cool, thanks!

Nice!

DMI-like organization

What does DMI stand for?

EA "civilisational epistemics" project / org idea
Or:  an EA social media team for helping to spread simple and important ideas

Below I describe a not-at-all-thought-through idea for a high impact EA org / project. I am in no way confident that something like this is actually a good idea, although I can imagine it being worth looking into. Also, for all I know people have already thought about whether something like this would be good. Also, the idea is not due to me (any credit goes to others, all blame goes to me).

Motivating example (rough story which I haven't verified, probably some details are wrong): in the US in 2020 COVID testing companies had a big backlog of tests, and tests had a relatively short shelf life during which analysis would still be useful. Unfortunately, analysis was done with a "first in first out" queue, meaning that testing companies would analyse the oldest tests first, often meaning they wasted precious analysis capacity on expired tests. Bill Gates and others publicly noted that this was dumb and that testing companies should flip the queue and analyse the newest tests first (or maybe he just said that testing companies should be paid for "on time delivery of results" rather than just "results"). But very few people paid attention, and the testing companies didn't change their systems. This had very bad consequences for the spread of the pandemic in the US.

Claim: creating common knowledge of / social media lobbying pressure related to the right idea can make the right people know about it / face public pressure, causing them to implement the idea.

Further claim: this is a big enough deal that it's worth some EA effort to make this happen.

The suggested EA project / org: work to identify important, simple, and uncontroversial ideas as they arise and use social media to get people to pay attention to them.

Nice, thanks for those links, great to have those linked here since we didn't point to them in the report. I've seen the Open Phil one but I don't think I'd seen the Animal Ethics study, it looks very interesting.

Thanks for raising the point about speed of establishment for Clean Meat and Genetic Circuits! Our definition for the "origin year" (from here) is "The year that the technology or area is purposefully explored for the first time." So it's supposed to be when someone starts working on it, not when someone first has the idea. We think that Willem van Eelen started working on developing clean meat in the 1950's, so we set the origin year to be around then. Whereas as far as we're aware no-one was working on genetic circuits until much later. 

At the moment I'm not sure whether the supplementary notes say anywhere that we think van Eelen was working on developing clean meat in the 50's, I think Megan is going to update the notes to make this clearer.

Thanks both (and Owen too), I now feel more confident that geometric mean of odds is better!

(Edit: at 1:4 odds I don't feel great about a blanket recommendation, but I guess the odds at which you're indifferent to taking the bet are more heavily stacked against us changing our mind. And Owen's <1% is obviously way lower)

(don't feel extremely confident about the below but seemed worth sharing)

I think it's really great to flag this! But as I mentioned to you elsewhere I'm not sure we're certain enough to make a blanket recommendation to the EA community.

I think we have some evidence that geometric mean of odds is better, but not that much evidence. Although I haven't looked into the evidence that Simon_M shared from Metaculus.

I guess I can potentially see us changing our minds in a year's time and deciding that arithmetic mean of probabilities is better after all, or that some other method is better than both of these.

Then maybe people will have made a costly change to a new method (learning what odds are, what a geometric mean is, learning how to apply it in practice, maybe understanding the argument for using the new method) that turns out not to have been worth it.

Nice, thanks for this!

I mean, depending on what you mean by "an okay approach sometimes... especially when you want to do something quick and dirty" I may agree with you! What I said was:

This is not Tetlock’s advice, nor is it the lesson from the forecasting tournaments, especially if we use the nebulous modern definition of “outside view” instead of the original definition.

I guess I was reacting to the part just after the bit you quoted

For an entire book written by Yudkowsky on why the aforementioned forecasting method is bogus

Which I took to imply "Daniel thinks that the aforementioned forecasting method is bogus". Maybe my interpretation was incorrect. Anyway, seems very possible we in fact roughly agree here.

Re your 1, 2, 3, 4: It seems cool to try doing 4, and I can believe it's better (I don't have a strong view). Fwiw re 1 vs 2, my initial reaction is that partitioning by outside/inside view lets you decide how much weight you give to each, and maybe we think that for non-experts it's better to mostly give weight to the outside view, so the partitioning performed a useful service. I guess this is kind of what you were trying to argue against and unfortunately you didn't convince me to repent :).

Here are some forecasts for near-term progress / impacts of AI on research. They are the results of some small-ish number of hours of reading + thinking, and shouldn't be taken at all seriously. I'm sharing in case it's interesting for people and especially to get feedback on my bottom line probabilities and thought processes. I'm pretty sure there are some things I'm very wrong about in the below and I'd love for those to be corrected.

1. Deepmind will announce excellent performance from Alphafold2 (AF2) or some successor / relative for multi-domain proteins by end of 2023; or some other group will announced this using some AI scheme: 80% probability
2. Deepmind will announce excellent performance from AF2 or some successor / relative for protein complexes by end of 2023; or some other group will announced this using some AI scheme: 70% probability
3. Widespread adoption of a system like OpenAI Codex for data analysis will happen by end of 2023: 20% probability

I realise that "excellent performance" etc is vague, I choose to live with that rather than putting in the time to make everything precise (or not doing the exercise at all).

If you don't know what multi-domain proteins and protein complexes are, I found this Mohammed Al Quraishi blog very useful (maybe try ctrl-f for those terms), although maybe you need to start with some relevant background knowledge. I don't have a great sense for how big a deal this would be for various areas of biological science, but my impression is that they're both roughly the same order of magnitude of usefulness as getting excellent performance on single-domain proteins was (i.e. what AF2 has already achieved).

As for why:

80% chance that excellent AI performance on multi-domain proteins is announced by end of 2023

• Top reasons for event happening
  • Deepmind apparently wants to tackle protein complexes ("Based on this and DeepMind’s repeated assertions…") and multi-domain proteins seem like a stepping stone for that
  • Mohammed Al Quraishi already thought AF2 dealt with multi-domain proteins "just fine" in Dec 2020
  • It's an extremely similar problem to the one they already cracked (single domains) and it seems tractable
• Top reasons against
  • Maybe they won't announce it, because it's not newsworthy enough; or they'll bundle it with some bigger announcement with lots of cool results (resulting in delayed announcement)
• Other reasons against
  • In particular, the results from the next CASP competition will presumably be announced in December 2022; if they haven't cracked it by then, maybe we won't hear about it by end of 2023
    • They'd need to get there by April 2022  (I think that is the submission deadline for CASP)
  • Maybe it will turn out to be way less tractable than expected
  • Maybe Deepmind will have other, even more pressing priorities, or some key people will unexpectedly leave, or they'll lose funding, or something else unexpected happens
• Key uncertainties
  • Are rival protein folding schemes targeting this?

70% chance that excellent AI performance on protein complexes is announced by end of 2023

• Top reasons for event happening
  • Deepmind apparently wants to tackle protein complexes ("Based on this and DeepMind’s repeated assertions…")
  • Mohammed Al Quraishi already thought it dealt with multi-domain proteins "just fine" in Dec 2020, and these are a stepping stone to protein complexes
  • There is quite a lot of data (though 10x less than for single proteins)
    • Unsure whether transfer learning (I maybe using the wrong term) is relevant here?
• Top reasons against
  • Maybe even if it's done by say mid 2023 it won't be announced until after 2023 because of Deepmind's media strategy
    • In particular, targeting a CASP would seem to require the high performance to be achieved by mid 2022; maybe this is the most likely scenario in worlds where Deepmind announces this before end of 2023
    • (although if Deepmind doesn't get there by CASP15, it seems like another group might announce something in say 2023)
  • Protein complexes are (maybe?) qualitatively different to single proteins
• Other reasons against
  • Maybe the lack of data will be decisive
  • Maybe Deepmind's priorities will change, etc, as in noted above in the multi-domain case
• Key uncertainties
  • Are rival schemes targeting this?

20% chance of widespread adoption of a system like OpenAI Codex for data analysis by end of 2023

(NB this is just about data analysis / "data science" rather than about usage of Codex in general)

• My "best guess" scenario
  • OpenAI releases an API for data science that is cheap but not free. In its current iteration, the software is "handy" but not more than that. A later iteration, released in 2023, is significantly more powerful and useful. But by the end of 2023 it is still not yet "widely used".
• Some reasons against event happening
  • Maybe Codex is currently not that useful in practice for data analysis
  • I think OpenAI won't release it for free so it won't become part of the "standard toolkit" in the same way that e.g. RStudio has
  • Things like RStudio take a long time to diffuse / become adopted
    • E.g. my guess is ~5 years to get 25% uptake of for ipython notebook or rstudio by data scientists, or something like that
• Key uncertainties
  • How much are OpenAI going to push this on people?
    • How much are they pushing the data science aspect particularly?
  • Will this be ~free to use or will it be licensed?
  • How quickly will it improve? How often does OpenAI release improved versions of things?
  • How fast did ipython notebook/rstudio get adopted?
  • How much has the GPT-3 API been used so far?
• Some useful links
  • From the OpenAI website: "During the initial period, OpenAI Codex will be offered for free"
  • This guy at VentureBeat thinks that Microsoft will make the profits from Codex (but that doesn't seem to rule out it being widely used to assist with data analysis; just implies that the data analysis software will be owned by microsoft, I guess?)
  • The Verge says "although Codex is initially being released as free API, OpenAI will start charging for access at some point in the future."
  • The impression I get from Appendix H of OpenAI's paper on Codex is that they expect at least fairly wide adoption of Codex or something similar