All of Sanjay's Comments + Replies

The person I spoke to at the party said that he knew somebody who had a fungal infection and was likely to die from it.

I don't know much about antifungals, but I infer from his comment that we don't have enough antifungals to cover all of the potential fungal infections.

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Jenny Kudmowa
To my knowledge, there are a few (not actually that many) existing antifungals, but as I commented above, they mostly aren't very good, and in several deadly fungal infections they are almost pointless. Also, when a new fungal pathogen comes out, it might be harmless, or it might be big trouble, nobody can predict that. A good example I've seen mentioned a few times is Candida Auris (pretty serious and often deadly fungal infection) that emerged in 2009 independently in several regions of the world, pretty much out of nowhere. And the scary thing is that it was drug-resistant from the start! I think researchers aren't quite sure why it emerged, but it could be related to climate change.

According to someone I chatted to at a party (not normally the optimal way to identify top new cause areas!) fungi might be a worrying new source of pandemics because of climate change.

Apparently this is because thermal barriers prevented fungi from infecting humans, but because fungi are adapting to higher temperatures, they are now better able to overcome those barriers. This article has a bit more on this:

https://theecologist.org/2026/jan/06/age-fungi

Purportedly, this is even more scary than a pathogen you can catch from people, because you can catch th... (read more)

Hi Sanjay,

When people ask me "What is one area or issue you wish people paid more attention to in global health?", I almost always say fungal diseases.

I co-authored some reports on fungal infections (e.g., this one), and my impression is that it is indeed very plausible and well-recognized by experts that fungal infections will rise in a major way as a result of climate change, though I have not seen any guesses / estimates of how large the additional burden could be.

I think the more important point is that, regardless of climate change, fungal diseases ar... (read more)

4
NickLaing
Thanks this is super interesting and definitely concerning. FWIW within the non-EA Global Health Community this has been a topic of conversation for the last 3-4 years. It is potential threat, but still seems like a super low percentage Xish-risk, because... a) We haven't actually seen anything terribly dangerous happen yet b) Antifungal medications are there, and if there was a super-dangerous-mass fungal threat I suspect we could make better ones pretty quicksmart. But yes this is far from guaranteed. As a side note there are already plenty of pathogens we catch from the soil like anthrax and tetanus, as well as worms like hookworm!
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feijão
The idea of fungi evolving to infect humans and resulting in apocalypse underpins the premise of the famous game and TV series "The Last of Us" Given the series' critical acclaim and popularity, I wonder if it also demonstrates potential for engaging the public with this topic through mainstream popular media.
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clavin399
This idea gets discussed in infectious disease circles, but it is often framed more dramatically than the evidence supports. Fungi adapting to higher temperatures is real, Candida auris is a good example, but most fungi still struggle to survive in the human body and spread efficiently between people. Soil exposure already exists today, yet serious fungal infections remain rare and mostly affect immunocompromised individuals. It is a risk worth monitoring, not a hidden pandemic waiting to explode, which is likely why it has not triggered broader alarms outside specialist research.

For anyone who got excited about the title, it may well be the case that you cannot just buy far UVC. I had a look at https://aerolamp.net/products/devkit and it doesn't seem to ship to countries outside the US, so if you're one of the 95% of the world's population that isn't American, this doesn't seem to be an option.

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jvb
We're hopeful to change that soon
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Thomas Kwa🔹
Nukit ships to many countries.

Great to see you thinking about this, good work.

I would have expected to see more on India.

  • In particular, Indian companies above a certain size are required by law to donate 2% of profits
  • Given the enormous wealth disparity, companies can make a lot of money, donate locally within India, and still find extremely poor people and relatively good giving opportunities
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Joel Tan🔸
Hi Sanjay! Impactful Giving was incubated by CE, and its founders Chetan & Jesse are currently working on effective giving promotion in India. I understand that it's been challenging, and getting the general public to give has been particularly difficult, though the HNWI side of things has shown more promise. We introduced them to Upadhyaya Foundation earlier in 2025, and they've worked together (with India Animal Fund) to start a new India Animal Welfare Funding Circle, which brings donors together to promote both evidence-based giving in AW and also more coordination/information sharing between grantmakers. I'm fairly excited to see how things develop from here. I will say that the difficulty of promoting effective giving to the (relatively poorer) public in India informed our decision to focus on high-income East Asia, where it's plausible that the man on the street (if sold on the ideas of effective giving) is able and willing to give a few thousand a year. Cheers, Joel

This post has plenty on "how to make EA cool", but the title promised "Why make EA cool" as well. I think the post is a bit light on the why.

Maybe you don’t think being cool matters. That’s a fine opinion if you’re ok with EA being a group of 10,000 people, ~70% male and ~75% white, circularly spending Dustin Moskovitz’s money. 

But imagine a movement of a million people. A million people donating a percentage of their income to create a community fund as large as Open Phil’s. A million people working at high-impact organizations. 

There's been ple... (read more)

I feel like this is a first step on the road to something that might be quite powerful at communicating chicken/hen welfare.

The thing that was missing for me was that when I was "playing" at being a chicken in the different environments, I didn't see the point. I did various things, but found them boring.

The easiest way to better gamify this is to explain upfront that the user will be asked to guess what sort of environment the chicken is in, so the user can better orient themselves to what they are trying to achieve.

A better way to gamify is to add a welf... (read more)

Answer by Sanjay3
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This is an important and valuable question, thank you for raising it. I'll split my observations into two effects:

  1. Malthusian effects
  2. Benefits of scale

Malthusian effects

Other responses have referred to Malthusian effects, by which I mean the concern that with only finite resources, the resources will be spread between more people, and each person will have a worse quality of life.

Benefits of scale

Creating another person doesn't only create another mouth to feed. It also creates another source of ideas and creativity. 

For example, each new birth has the ... (read more)

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tootlife
Thank you for laying out the "Malthusian effects" vs. "benefits of scale" framework so clearly. As someone engaging with the Effective Altruism movement's ideas from an outside perspective, I find this a helpful way to structure the problem. However, from my viewpoint, I have a deep concern with the "benefits of scale" argument as it's presented. When we justify adding a million people by the chance that one of them might be the next Norman Borlaug, we are judging human lives based on their instrumental value—what they might produce for the rest of us. This framing implicitly creates a hierarchy of human worth. The value of the 999,999 non-innovators becomes secondary, justified only by the possibility of the one "genius" they might help produce. They become a means to an end, not ends in themselves. This is precisely the logic that opens the door to eugenics. To be clear on what I mean by this, eugenics is the belief that humanity can and should be improved by controlling reproduction—encouraging births among those with "desirable" traits while discouraging or preventing births among those with "undesirable" traits. At its very core, it is a system of valuing people instrumentally based on their perceived biological or social fitness. If we accept the principle that a person's worth is tied to their potential intelligence or creativity, what logical principle stops us from concluding that lives with less of that potential are less worth creating or protecting? This brings me back to my central concern. For an observer like myself, it seems the only robust defense against these incredibly dangerous historical ideas is to build an ethical framework based on the inherent value of every single life, regardless of whether that person becomes a saviour or lives a simple, ordinary existence.

This post (especially this section) explores this. There are also some ideas on this website. I've copied and pasted the ideas from that site below. I think it's written with a more international perspective, but likely has some overlap with actions which could be taken by Americans.

... (read more)

For people who haven't clicked through, it might be worth mentioning that this is about insects being used as livestock for other animals.

This matters because you might consider insect farming for human consumption to be more morally ambiguous. (If insects turn out not to be sentient, and insect consumptions displaces consumption of larger, actually-sentient animals, this could be a positive for the world).

However, insects being used as livestock is more clearly negative.

I think this is the same consultation flagged by James here, right? If so, might be worth flagging that.

I really appreciate having these flagged on the forum, so thank you, I think it's a valuable public service

Glad to see you raising this. I raised a related question here (has a slightly more US-centric angle to it). In that post I do suggest some interventions, but there's not a lot of careful research behind it.

2
jackva
Yes, I saw this and was happy for it to exist. What I am trying to say is that this being one of the longest treatments on this to exist feels like a failure / blind spot of the community. We're in the midst of very severe systemic changes, domestic and international, and -- ideally -- there'd be lots of thorough analysis on the forum and elsewhere.

I've upvoted this comment and disagree-voted it. I was initially prone to be dubious of the suggestion. I think lots of us are motivated by important outcomes like children not dying, and linking aid to national self-interest seemed problematic, because children not dying (or other good outcomes) are not the same as national self-interest. Optimising for one is likely to lead to different aid interventions than optimising for the other. 

However I've warmed somewhat to the suggestion.

  • Nick rightly pointed out that politics risks toggling the supply up a
... (read more)
Answer by Sanjay3
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I think this is definitely an interesting question, and I can see how it has some strategic value for organisations doing scenario planning for the future. 

As far as I'm aware (based on conversations with people closer to US government than me) there was an element of "pandemic fatigue" in US government. The government was painfully aware that they had spent a huge amount on COVID already. Proposals to spend even more on an "Apollo programme" or other efforts to ensure we don't have this problem again didn't seem appealing, because some many other priorities had been put on hold and were vying for attention.

I don't remember hearing much about polarisation being an important driver.

Good question, I'm sorry nobody has replied yet. I don't feel like I'm much of an expert on this, so others may be better positioned than me.

My sense is that yes, this may well be impactful, especially if it is clearly communicated. This is a meaningful move, and one that the party will feel -- all parties need financing.

To maximise effectiveness, you likely need to inform the right people. By all means, do tell your MP (assuming your MP is a Labour MP). Saying that you're willing to leave the Labour party makes you less likely to vote for them in future, ... (read more)

Good point here:

Another lever to consider, rather than ‘punish government for cutting aid’, is ‘telling the government that effectiveness matters to me when they decide what to cut’. Don’t know how to compare those.

If I'd given more thought to the draft letter, I might have said more on this.

I'm conscious that Jenny Chapman (who is taking over from Anneliese Dodds as Development minister) doesn't seem to have much background in development. 

If someone wrote an email which conveyed acceptance of the reality (cuts are going to happen, whether I like it ... (read more)

Sorry I didn't see this sooner. Yes, I do believe that an email will be more likely to be effective if it looks like it's not copied and pasted. My basis for this is that when I supported a group of people to campaign on ODA about 4 years ago, I asked several people, including veteran campaigners and people who have worked for an MP replying to emails for them. Those people explained that if the email looks like a copy-and-paste/boilerplate email, they will assume that it was driven by a campaign group, which carries less weight than if you do it yourself.... (read more)

Strong upvoted. I'm definitely among the people who saw the headlines, thought that it was a simple case of Musk losing, and didn't appreciate that it's potentially much less favourable to OpenAI that it appears from the headlines.

Thanks for the question. Happy to set out how I think about this, but note that I haven't researched this deeply, and for several parts of this argument, I could imagine myself changing my mind with a bit more research.

  • Firstly, we’re not considering the aid spend in isolation. Rather, the impact of our actions may be to redirect spend from one usage to another, so we're comparing to some counterfactual spend, which is typically likely to be some sort of spend which leads to (probably) some sort of economic activity in a developed economy.
  • Secondly, I think
... (read more)
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Vasco Grilo🔸
Thanks, Sanjay! Great points. I agree it is unclear whether campaigning against aid cuts is beneficial or harmful to animals. However, treating the effects on animals as neutral requires the effects on animals to be much smaller in magnitude than the effects on humans. I can easily see the effects on animals being negative and larger in magnitude. So I do not know whether campaigning against aid cuts is beneficial or harmful. To clarify, I distinguish between these 2 possibilities for "effect on animals" + "effect on humans" = "overall effect": * "Small positive/negative number" (effect on animals) + "medium positive number" (effect on humans) = "medium positive number" (overall effect). One can neglect the effects on animals. * "Medium/Large positive/negative number" + "medium positive number" = "medium/large positive/negative number". One cannot neglect the effects on animals. I think the 2nd bullet corresponds to the actual situation.

Thanks Larks. Agree, both of those ideas are already in the template

This seems superficially like a great idea, but I think it works better for, say, the centre for effective aid policy (if it still existed).

  • It's easier to decide which things to prioritise if you've gone through the things that UK aid actually does and worked out which are better and which are less good.
  • Your ask will be more effective if you have a good handle on which deprioritisation are a no-go politically (eg are you suggesting deprioritising work in Gaza or Ukraine? Would the politics of that work? Does any of your suggestions bump up against anythin
... (read more)
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Larks
The CGD suggests spending on migrants inside the UK as a currently elevated item that could be reduced significantly. EDIT: though now I think about it, "drop the Chagos Islands deal" could be a politically viable alternative source of funds, give then $8bn cost of the extremely unpopular deal is sort of like inefficient foreign aid. (Though the $8bn is not an annual figure).

I haven't thought about this in great depth, so I'm very open to the possibility that this topic should be deprioritised. I haven't understood your rationale, so I hope you don't mind if I probe further. 

Firstly, a lot of the concerns expressed here I think are extremely unlikely. I do not think there is any serious risk that Trump will send the military after, or otherwise seriously harass, former government employees.

I guess I'd be somewhat interested to know why serious harassment is so unlikely. The sources that I cited seemed to be quite worrying... (read more)

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River
  I think a lot of where we differ is in how much we trust the media when it comes to Trump. I've generally found that media will report ordinary things as though they were extraordinary and bad, will take the worst possible interpretation of ambiguous quotes, and do whatever else they think will keep people irrationally afraid of Trump. Take the particular claim that you made your centerpeice - that Musk was throwing around his wealth to support Trump's nominees. "Rich American uses wealth to influence politicians" is not exactly news - that happens every day on both sides of the aisle. And what you put in block quotes was just that fact wrapped in hyperbolic language. I looked very briefly at your seven sources. All were during the election and all seemed to draw on the same quote: "Trump said that if 'radical left lunatics' disrupt the election, 'it should be very easily handled by — if necessary, by National Guard, or if really necessary, by the military.'" The author somehow read that as "Trump has expressed support for using government force against domestic political rivals." Talk about a straw man! Trump was suggesting using the military to ensure the election happens. That may be unwise and unprecedented and predictably totally unnecessary, but it is nothing like using the military against political rivals. This is the press's standard MO when reporting on Trump. So when they say "100 threats to whatever" I just assume that few if any of the things on their list are actually what they are claimed to be. I agree that people have that fear. I do not think it is warranted. And I think indulging an unwarranted fear is generally a bad idea - you just incentivize people to have unwarranted fears in the future. We need political rhetoric to cool down right now, not heat up. For your bulleted list of bad things, I agree that many of them are unqualifiedly bad. A few of them I have more nuanced views on. But I don't want to go point by point through it, as I don

It does sound sort of interesting, but I don't think I have a clear picture of the theory of change. How does the dashboard lead to better outcomes? If the theory of change depends on certain key people (media? Civil servants? Someone else?) making use of the dashboard, would it make sense to check with those people and see if they would find it useful? Should we check if they're willing to be involved in the creation process to provide the feedback which helps ensure it's worth their while to use it?

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Nathan Young
I think it would allow many very online slightly anxious people to note how the situation is changing, rather than plug their minds into twitter each day. I think the bird flu site helped a little in my part of twitter to tell people to chill out a bit and not work themselves into a frenzy earlier than was necessary. At least one powerful person said it was cool.  I think that civil servants might use it but I'm not sure they know what they want here and it's good to have something concrete to show.

Shortly after I wrote this, the news reported nationwide protests on topics pretty aligned you what in talking about here. This might mean that my assessment of neglectedness should be updated

I have now reviewed and edited the relevant section.

My feeling when I drafted it was as per Ozzie's comment -- as long as I was transparent, I thought it was OK for readers to judge the quality of the content as they see fit.

Part of my rationale for this being OK was that it was right at the end of a 15-page write-up. Larks wrote that many people will read this post. I hope that's true, but I didn't expect that many people would read the very last bits of the appendix. The fact that someone noticed this at all, let alone almost immediately after this post was published, was an update for me.

Hence my decision to review and edit that section at the end of the document, and remove the disclaimer.

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Dylan Richardson
I actually like that you did this; there's such little information on the news "firehose" right now that a possible accuracy/content tradeoff is entirely reasonable! 

You wrote:

Consider these types of questions that AI systems might help address:

  • What strategic missteps is Microsoft making in terms of maximizing market value?
  • What metrics could better evaluate the competence of business and political leaders?
  • Which public companies would be best off by firing their CEOs?
  • <...>

I'm open to the possibility that a future AI may well be able to answer these questions more quickly and more effectively than the typical human who currently handles those questions.

The tricky thing is how to test this.

Given that these are not e... (read more)

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Ozzie Gooen
Thanks for raising the concern! I agree that testing it is difficult. I partially addressed this above in the section on "Strategy and Verifiability".  I would flag that people should arguably be equally suspicious of most humans. As we come up with various tests and evals, I expect that mostly the best AIs will have mediocre results, and most prominent humans will just refuse to be tested (we can still do lighter evals on public intellectuals and such using their available works, but this will be more limited). Prediction markets seem like a pretty good test to me, though they are only one implementation.  I expect that with decent systems, we should have new "epistemic table stakes" of things like: * Can do forecasting in a wide variety of fields, at least roughly as good as Metaculus forecasters with say 10hrs per question * In extensive simulations, has low amounts of logical inconsistencies * Flags all claims that users might not agree with * Very low rates of hallucinations * Biases have been extensively tested under different situations * Extensive red-teaming by other top AI systems * Predictions of how well this AI will hold up, in comparison to better AI intellectual systems in 10 to 40 years. * Full oversight/visibility of potential conflicts of interest. (I'm not saying that these systems will be broadly-trusted, just that they will exist. I would expect the smarter people at least to trust them, in accordance to their evals.)

Can you give an indication of how common the problem is? (ie how often do papers get lost/deleted?) My intuition says not very often, and when it does happen it's most likely to be the least useful papers, but I could believe my intuition is wrong.

3
SofiiaF
Thanks for the question! Should have provided context. With new executive orders, entire databases are being deleted of open sourc public academic data. Efforts to retain access are kind of disparate and keeping track is hard, whilst datasets are too big for lone people to download and archive or host. For example, here's a short excerpt of just some of the deletions since yesterday (started collating to keep track in the masterdoc, hoping to make a website/distribution etc):   PAPERS AND TOPICS DELETED or UNAVAILABLE: (as of 2/2/25) AND ALTERNATIVE SOURCES (IF AVAILABLE)   Broad topics: * HIV and Sexual Health * https://www.cdc.gov/hiv/testing/index.html * HIV hub https://www.cdc.gov/hiv/site.html * Contraceptive guidelines https://www.cdc.gov/contraception/hcp/contraceptive-guidance/ * STI treatment guidelines https://www.cdc.gov/std/treatment-guidelines/adolescents.htm * Discussing HIV and Sexual Health resources https://www.cdc.gov/healthyyouth/healthservices/infobriefs/birth_control_information.htm * STIs in adolescents treatments https://www.cdc.gov/std/treatment-guidelines/adolescents.htm * Up from 17:46 GMT 2/2 * Contraception guidance for healthcare providers https://www.cdc.gov/contraception/hcp/contraceptive-guidance/ * Preventing HPV in women https://www.cdc.gov/hiv/prevention/index.html * STI statistics https://www.cdc.gov/sti-statistic * Gender and diversity * Disability inclusion * Youth and childhood * Diseases and outbreaks, global health * Health disparities in TB, HIV, STDS and hepatitis https://www.cdc.gov/health-disparities-hiv-std-tb-hepatitis/ * Vaccines * Vaccine guidance https://www.cdc.gov/vaccines/hcp/acip-recs/index.html *   * Misc * A-Z Index of Birth Defects https://www.cdc.gov/ncbddd/sitemap.html * Intellectual Disabilities Information Hub https://www.cdc.gov/ncbddd/developmentaldisabilities/facts-about-intellectual-disability.html * Contact CDC https://www.cdc.gov/contact

I don't think bringing the ISS down in a controlled way is because of the risk that it might hit someone on earth, or because of "the PR disaster" of us "irrationally worrying more about the ISS hitting our home than we are getting in their car the next day".

Space debris is a potentially material issue.

  • There are around 23,000 objects larger than 10 cm (4 inches) and about 100 million pieces of debris larger than 1 mm (0.04 inches). Tiny pieces of junk might not seem like a big issue, but that debris is moving at 15,000 mph (24,140 kph), 10 times faster tha
... (read more)
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Arepo
I'm deeply concerned about space debris, but I don't think it alone could justify this project. A 'controlled' descent sounds like it's about targeting a specific landing spot - an 'uncontrolled' descent could still lower the ISS sufficiently fast as to minimise its chance of hitting orbiting debris (it probably lowers it faster!). Also the ISS is also already well within Earth's atmosphere, and the lower it gets, the shorter the life of debris hitting it would be due to atmospheric resistance, and it would presumably be relatively easy to control it from hitting anything near the start of its descent, when you can choose when to start the process and only run serious risk as it started to lose control 0 in the lower, thicker atmosphere.
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NickLaing
Thanks Sanjay - I'm going off NASA's public facing materials, where they don't mention space debris as a potential consideration in controlled vs. Uncontrolled descent. They mention that as a reason why they don't destroy it in situ or try and take the ISS to higher orbit. I completely agree, if space debris was a serious consideration then it would be a while different equation.

A donor-pays philanthropy-advice-first model solves several of these problems.

  • If your model focuses primarily on providing advice to donors, your scope is "anything which is relevant to donating", which is broad enough that you're bound to have lots of high-impact research to do, which helps with constraint 1.
  • Strategising and prioritisation are much easier when you're knee-deep in supporting donors with their donations -- this highlights the pain points in making good giving decisions, which helps with constraint 2.
  • If donors perceive that the research is w
... (read more)

Hi Ozzie, I typically find the quality of your contributions to the EA Forum to be excellent. Relative to my high expectations, I was disappointed by this comment.

> Would such a game "positively influence the long-term trajectory of civilization," as described by the Long-Term Future Fund? For context, Rob Miles's videos (1) and (2) from 2017 on the Stop Button Problem already provided clear explanations for the general public.

It sounds like you're arguing that no other explanations are useful, because Rob Miles had a few videos in 2017 on the issue?

Thi... (read more)

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Ozzie Gooen
Thanks for the comment Sanjay!  I think your points are quite fair.  1. I agree my sentence "It sounds like you're arguing that no other explanations are useful, because Rob Miles had a few videos in 2017 on the issue?" was quite overstated. I apologize for that. That said, my guess is that I'm really not sure if presence of the Rob Miles videos did decrease the value of future work much. Maybe by something like 20%? I could also see situations where the response was positive, revealing that more work here would be more valuable, not less.  All that said, my guess is that this point isn't particularly relevant, outside of what it shows of our arguing preferences and viewpoints. I think the original post would have a similar effect without it. That's relevant to know, thanks! This wasn't my takeaway when reading it (I tend to assume that it's clear that funds have opportunity costs, so focused more on the rest of the point), but I could have been wrong. 

Donors contribute to these funds expecting rigorous analysis comparable to GiveWell's standards, even for more speculative areas that rely on hypotheticals, hoping their money is not wasted, so they entrust that responsibility to EA fund managers, whom they assume make better and more informed decisions with their contributions.

I think it's important that the author had this expectation. Many people initially got excited about EA because of the careful, thoughtful analysis of GiveWell. Those who are not deep in the community might reasonably see the branding "EA Funds" and have exactly the expectations set out in this quote.

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Linch
Right now, we already do quite a few things to manage expectations and make the speculative nature of our grants as upfront as possible. Do you have suggestions for how we can improve on that front?
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Linch
I think it's very plausible that EA Funds, or LTFF specifically, should rebrand to remove "EA" from the name. I think it'd be a bit of a loss because I view us as trying to do something fully central to what I believe to be the core of EA: trying to make the best decisions we can given the limited resources we have. But communication of what "EA" means to different people have been at best mixed, and it's understandable if other people take a different position (eg if they believe that EA is about making high-quality decisions about altruistic activities with uniformly high rigor and transparency).  And this isn't really a question with a truth of the matter. Words are made by men, etc.  So plausibly we should move away from that brand, for this and several other reasons.

I'm working from brief conversations with the relevant experts, rather than having conducted in-depth research on this topic. My understanding is:

  • the food security angle is most useful for a country which imports a significant amounts of its food; where this is true, the whole argument is premised on the idea that domestic food producers will be preserved and strengthened, so it doesn't naturally invite opposition. 
  • the economy / job creation angle is again couched in terms of "increasing the size of the pie" -- i.e. adding more jobs to the domestic ec
... (read more)

When advocating that governments invest more in alt proteins, the following angles are typically used:

  • climate/environmental
  • bioeconomy (i.e. if you invest in this, it will create more jobs in your country)
  • food security

I understand the latter two are generally popular with right-wing governments; either of these two positions can be advanced without referencing climate at all (which may be preferable in some cases for the reasons Ben outlines)

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D0TheMath
The second two points don’t seem obviously correct to me. First, the US already has a significant amount of food security, so its unclear whether cultivated meats would actually add much. Second, If cultivated meats destroy the animal agriculture industry, this could very easily lead to a net loss of jobs in the economy.
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huw
Do you have any sense of how they play against the concerns of the much more powerful food & agriculture lobby?

I can confirm that there exists at least NGO who has this type of risk on their radar. I don't want to say too much until we have gone through the appropriate processes for publishing our notes from speaking with them. 

If any donors want to know more, feel free to reach out directly and I can tell you more.

An application I was expecting you to mention was longer term forecasts. E.g. if there was a market about, say, something in 2050, for example, the incentives for forecasters are perhaps less good, because the time until resolution is so long. But a "chained" forecast capturing something like "what will next year's forecast say" (and next year's forecast is about the following year's forecast, and so until you hit 2050, when it resolves to the ground truth).

This assumes that forecasters are less effective when it comes to markets which don't resolve for a long time.

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Ben Millwood🔸
In principle, normal markets should work this way. That is, if there's a market that won't settle for a year, but you think next week the price is going to go up a bunch, you will want to buy it now, and then sell it when the price goes up. If lots of people do this, the price goes up now, instead of next week (and in fact, if everyone saw that coming, it went up last week instead, and so on). If the market is reasonably liquid and/or there are market makers, you're not committing yourself until settlement, you can just sell out of your position when the price corrects (or when you give up on it doing so). If, on the other hand, the market is not reasonably liquid, then I don't think iterated markets fix your problem, because people don't have a strong reason to expect the next market forecast to match the actual probability, so they can't profit by trading on that basis.
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Ozzie Gooen
Good point. I think this sort of use case is very important. I think that this problem is probably better addressed with other methods rather than straightforward sequences of separate questions, but I imagine the latter will occasionally be useful as a solution. I've also been thinking about this use case recently. I think I like the term "progressive" forecast, but I'm curious to get more takes!

In 2020, we at SoGive were excited about funding nuclear work for similar reasons. We thought that the departure of the MacArthur foundation might have destructive effects which could potentially be countered with an injection of fresh philanthropy.

We spoke to several relevant experts. Several of these were with (unsurprisingly) philanthropically funded organisations tackling the risks of nuclear weapons. Also unsurprisingly, they tended to agree that donors could have a great opportunity to do good by stepping in to fill gaps left by MacArthur. 

There... (read more)

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Benjamin_Todd
Thanks that's helpful background! I agree tractability of the space is the main counterargument, and MacArthur might have had good reasons to leave. Like I say in the post, I'd suggest people think about this issue carefully if you're interested in giving to this area.

Thanks Larks, I definitely agree with your characterisation of Kevin Esvelt as the bio guy. An error crept into our notes but is now corrected. 

Could someone please explain how much extra value this adds given that we already have the Cambridge declaration?

det
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As an outsider to the field, here are some impressions I have:

  • NY declaration is very short and uses simple language, which makes it a useful tool for communicating with the public. Compare to this sentence from the Cambridge declaration:

The neural substrates of emotions do not appear to be confined to cortical structures. In fact, subcortical neural networks aroused during affective states in humans are also critically important for generating emotional behaviors in animals.

  • The Cambridge declaration is over a decade old. Releasing a similar statement is an
... (read more)

If the authors of this post haven't indicated what their star signs are, how do I know if I believe what they say?

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Ivan Burduk
While our star signs may be relevant for optimizing 1-1 matches (sorry, we're not compatible), we don't have evidence to suggest there's any influence of star signs on the ability to evaluate the use of star signs to optimize 1-1 matches. We therefore recommend against using the lack of knowledge of our star signs as a reason to not believe our claims.

Can you say any more about what you plan to do?

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alene
Yes! Let's talk, Sanjay!! To summarize: As partial owners of corporations, shareholders have some power to protect the corporation’s interests. For example, when an investigation revealed mistreatment of Costco’s birds, two shareholders stepped into Costco’s shoes and sued Costco’s executives for making the company violate state animal neglect laws.

At the time, the comment was "it's not obvious, more rationale needed" -- i.e. I expressed sympathies for the proposal of transparency, but erred towards not doing it. 

I think the main thing which has changed is that it's a slightly more academic question now -- we no longer have the resource to run something like this. 

If, hypothetically, we did have the resource to run this again, would we default to asking funders to be transparent (rather than our previous default choice of not making this request)? I'm not sure -- as I say, it's a rather more academic question now.

Thanks very much for this, much appreciated. Your best guess of vaccines being less cost-effective than bednets and SMC, but not by an order of magnitude, sounds sensible.

Thanks very much for the comment, this is really interesting. The idea of explicitly adding in suicide risk is an interesting direction for the analysis, it sounds like good work. When you publish your paper, I'll be interested to consider whether the underlying estimates of the badness of depression (perhaps implicitly) already reflect the suicide angle.

At some point it might be useful to do a more careful compare and contrast between your method (using Pyne et al's paper) and our method (using the Sanderson paper). Given that the methods are quite differ... (read more)

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Stan Pinsent
The report is now public: https://forum.effectivealtruism.org/s/ykdScawzq59ntw9N3

I certainly would like to equip my toddler with more maths (and preferably computer science) skills than we see in schools. I was planning to remedy this by taking more time on teaching her the content myself (assuming she's willing!) I appreciate this won't work for everyone -- it's time-consuming and not every parent has great maths.

I'm hoping that I will be able to get into a routine of regular maths fun with Daddy. At first this will be the basics (my daughter can't talk yet, so she still has a lot to learn!), and then over time moving on to more advan... (read more)

I said this in another comment, but in case it gets missed, I just want to highlight that 1Day Sooner has shown an excellent attitude. When we reached out to them, they were consistently welcoming of the criticism and had constructive useful comments. I've found these virtues to be more common in the EA community than elsewhere, but I still like to call them out when I see it.

Thank you Josh. I've found 1Day Sooner's collaborative spirit to be exemplary here -- both being welcoming of the challenge and adding useful thoughts.

It seems intuitive to me that the following package of considerations may lead to vaccines and nets/SMC having roughly the same cost-effectiveness:

  • vaccines are 10x (ish) more expensive (bad for vaccines)
  • vaccines are more targeted at the most vulnerable ages (good for vaccines)
  • misc other considerations, like insecticide resistance (this is a bit hand-wavey at the moment, but I guess probably nets out to being
... (read more)

Sorry for asking about a minor detail, but Figure 3 in section 3.2.1 shows an internal validity adjustment of 90% for ITNs (top row of figure). I thought this was 95%? Am I misunderstanding how you're thinking about the adjustment in this document?

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GiveWell
Hi Sanjay - thanks for the close read! You're right that Figure 3 should read 95%, not 90% - we're working on correcting the figure and will update the post ASAP. Thanks again!

I've often thought that more quantification of the uncertainty could be useful in communicating to donors as well. E.g. "our 50% confidence interval for AMF is blah, and that confidence interval for deworming blah, so you can see we have much less confidence in it". So I think this is a step in the right direction, thanks for sharing, setting it out in your usual thoughtful manner.

Good question. 

It's also helpful because the wording of my post was meant to convey that "expert opinions tend to believe that the therapeutic alliance matters" (and not necessarily that I'm confident that that's the case). 

One of the papers that I referenced did flag that most of the studies are observational rather than experimental, which does validate your concern. (I think it was Arnow & Steidman 2014 which said this; I don't know if a more recent paper sheds more light on this).

I'm not planning to look into this topic in any depth, but perhaps someone more knowledgeable can give a more definitive answer.

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