Open Thread: What’s The Second-Best Cause?

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I’ve recently read the book Epic Measures, about the global burden of disease studes. One person involved in the studies had a habit of asking people who said their intervention was the most important, “what intervention is the second most important?”

It was intended as a gotcha, but I think it’s actually a really interesting question that sheds a lot of light on cause prioritization, and I’ve got a lot out of thinking about it.

So: people who prioritize a single charity, intervention, cause, or broad area in which to work, what charity/intervention/cause/broad area in which to work is second-best, and why?