I am currently donating equal amounts each month to 5 charities: Givewell, Life you save, animal charity evaluators, Seva, and Population Services International.
I want to donate as effectively as possible. I would appreciate any comments on my choices.
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In these cases, it's likely that you're getting better returns on credit card fees than giving directly to 22 charities, but marginally worse efficiency on processing costs, since it is probably around the same processing cost for all 22 charities, and also a processing cost at The Life You Can Save, etc.
Based on this, from a pure cost-to-programs view, I'd guess that if it is split up among at least 3 or 4 charities or more, the credit card fee benefits will outweigh the lower efficiency from the processing, so it is probably usually worth giving to something like the GiveWell maximum impact fund or TLYS, or the EA Funds, etc.
Also, I think getting all the benefits you also get from giving via those funds, like the ones esentorella describes, makes it especially worthwhile to continue giving via those funds (e.g. their research and understanding about how to optimally redistribute the funding).