Quick takes

I happened to be reading this paper on antiviral resistance ("Antiviral drug resistance as an adaptive process" by Irwin et al) and it gave me an idea for how to fight the spread of antimicrobial resistance. Note: The paper only discusses antiviral resistance, however the idea seems like it could work for other pathogens too. I won't worry about that distinction for the rest of this post. The paper states: This makes intuitive sense: If there was no fitness cost associated with antiviral resistance, there's a good chance the virus would already be resistant to the antiviral. More quotes: So basically it seems like if I start taking an antiviral, any virus in my body might evolve resistance to the antiviral, but this evolved resistance is likely to harm its fitness in other ways. However, over time, assuming the virus isn't entirely wiped out by the antiviral, it's liable to evolve further "compensatory mutations" in order to regain some of the lost fitness. Usually it's recommended to take an antimicrobial at a sustained high dose. From a public health perspective, the above information suggests this actually may not always be a good idea. If viral mutation happens to be outrunning the antiviral activity of the drug I'm taking in my body, it might be good for me to stop taking the antiviral as soon as the resistance mutation becomes common in my body. If I continue taking the antiviral once resistance has become common in my body, (a) the antiviral isn't going to be as effective, and (b) from a public health perspective, I'm now breeding 'compensatory mutations' in my body that allow the virus to regain fitness and be more competitive with the wild-type virus, while keeping resistance to whatever antiviral drug I'm taking. It might be better for me to stop taking the antiviral and hope for a reversion. Usually we think in terms of fighting antimicrobial resistance by developing new techniques to fight infections, but the above suggests an alternative path: F

Trump recently said in an interview (https://time.com/6972973/biden-trump-bird-flu-covid/) that he would seek to disband the White House office for pandemic preparedness. Given that he usually doesn't give specifics on his policy positions, this seems like something he is particularly interested in. I know politics is discouraged on the EA forum, but I thought I would post this to say: EA should really be preparing for a Trump presidency. He's up in the polls and IMO has a >50% chance of winning the election. Right now politicians seem relatively receptive to EA ideas, this may change under a Trump administration.

Quote from VC Josh Wolfe: https://overcast.fm/+5AWO95pnw/46:15

I am concerned about the H5N1 situation in dairy cows and have written and overview document to which I occasionally add new learnings (new to me or new to world). I also set up a WhatsApp community that anyone is welcome to join for discussion & sharing news. In brief: * I believe there are quite a few (~50-250) humans infected recently, but no sustained human-to-human transmission * I estimate the Infection Fatality Rate substantially lower than the ALERT team (theirs is 63% that CFR >= 10%), something like 80%CI = 0.1 - 5.0 * The government's response is astoundingly bad - I find it insane that raw milk is still being sold, with a high likelihood that some of it contains infectious H5N1 * There are still quite a few genetic barriers to sustained human-to-human transmission * This might be a good time to push specific pandemic preparedness policies

Longtermist shower thought: what if we had a campaign to install Far-UVC in poultry farms? Seems like it could: 1. Reduce a bunch of diseases in the birds, which is good for: a. the birds’ welfare; b. the workers’ welfare; c. Therefore maybe the farmers’ bottom line?; d. Preventing/suppressing human pandemics (eg avian flu) 2. Would hopefully drive down the cost curve of Far-UVC 3. May also generate safety data in chickens, which could be helpful for derisking it for humans Insofar as one of the main obstacles is humans' concerns for health effects, this would at least only raise these for a small group of workers.

I'm working on an article about gene drives to eradicate malaria, and am looking for biology experts who can help me understand certain areas I'm finding confusing and fact check claims I feel unsure about. If you are a masters or grad student in biology and would be interested in helping, I would be incredibly grateful.   An example of a question I've been trying to answer today: How likely is successful crossbreeding between subspecies of Anopheles Gambiae (such as anopheles gambiae s.s. and anopheles arabiensis), and how likely is successful crossbreeding between anopheles gambiae and other complexes?   If you know the answer to questions like these or would have an easy time finding it out, send me a dm! Happy to pay for your time.

Given how bird flu is progressing (spread in many cows, virologists believing rumors that humans are getting infected but no human-to-human spread yet), this would be a good time to start a protest movement for biosafety/against factory farming in the US.

Vaccines saved 150M+ lives over the past 50 years, including 100M+ infants and nearly 100M lives from Measles alone: https://www.gavi.org/vaccineswork/new-data-shows-vaccines-have-saved-154-million-lives-past-50-years https://www.who.int/news/item/24-04-2024-global-immunization-efforts-have-saved-at-least-154-million-lives-over-the-past-50-years