To maximize impact, focus on problems that are large in scale, relatively neglected, realistically solvable, and aligned with your skills and strengths.
The greatest impact often comes from working on important challenges that others overlook, where meaningful progress is possible and where your unique abilities can make a lasting difference.
Because the future could contain countless generations, even small reductions in existential risks may have enormous value, making careful reasoning, expected value thinking, and openness to crucial new evidence essential for doing the most good