I would argue the article is extremely pessimistic.
Yes, funds sometimes get misallocated or are given to people who have committed fraud.
More often, they go to hard-working researchers who really don't make that much at all...people who hate fake or misleading scientific claims more than the average taxpayer.
And yes, there's a replication crisis...that people are aware of working to address.
In short, I think the author uses an extremely broad brush: "The widespread inability of publicly funded researchers to generate valid, reproducible findings is a testament to the failure of universities to properly train scientists and instill intellectual and methodologic rigor."
And yet, scientific breakthroughs happen all the time and the world is better for it.
In short, maybe the author is burnt out or has only ever worked with poor colleagues? Or hasn't been funded in a while?
Most of the researchers I've met are honest and hard-working and doing their best to get it right, even in the face of challenging questions and strained resources.
> stated that from 2000 to 2010, nearly 80,000 patients were involved in clinical trials based on research that was later retracted.
we can't know if this is a good or bad number without context.
Good point. Unfortunately the Economist article referenced for this number is pay-walled for me and I am not sure if it indicates the total number of clinical trial participants during that time.
Your comment got me interested so I did some quick googling. In the US in 2009 there were 10,974 registered trials with 2.8 Million participants, and in the EU the median number of patients studied for a drug to be approved was 1,708 (during the same time window). I couldn't quickly find the average length of a clinical trial.
I expect 80,000 patients would be at most 1% of population of total clinical trial participants during that 10 year window, so this claim might be a bit over-emphasised (although it does seem striking at first read).