An approach to doing good is to come up with a metric for what constitutes good or bad, and then trying to do things that will optimally increase or decrease such metric, as the case may be.
If you do this, you have to be careful about what metric you choose.
If you have an ontology where you measure good by “number of people who feel benefited by you”, you might end up doing things like sending everyone you can a doughnut with a signed note. If instead your metric is “number of people classified as poor” you might do best to focus on interventions that get people just over the hump of poverty as defined by your scale. And so on.
Conscientious and systematic altruists tend to see problems with metrics like those above. They realize that “people impressed” and “being poor according to an economic metric” are not metrics that really carve nature at its joints.
Dissatisfied with misleading metrics, one then tends to look closer at the world and arrive at metrics that take into account the length of different lives, their quality, their instrumental effect in the world, how much are they exactly being benefited by the intervention relative to other cost-effective alternatives, and so on. And that’s how you get things like Quality Adjusted Life-Years (QALY), micromorts, and the happiness index.
This is, I think, all moving in the right direction. Metrics that make an effort to carve nature at its joints can provide new lenses to see the world. And looking through those lenses tends to generate novel angles and approaches to do a lot of good.
This is why today I will suggest we consider a new metric: The Hell-Index.
A country’s Hell-Index could be defined as the yearly total of people-seconds in pain and suffering that are at or above 20 in the McGill Pain Index (or equivalent)*. This index captures the intuition that intense suffering can be in some ways qualitatively different and more serious than lesser suffering in a way that isn’t really captured by a linear pain scale.

What does this metric suggest we should do to make the world better? Here is an idea (told as if narrated from the future):
Between 2030 and 2050 it was very common for people to wear Get-Out-Of-Hell-Free Necklaces. People had an incredible variety of custom-fit aesthetic and practical additives to their necklaces. But in every single one of them, you could rest assured, you would find a couple of doses of each of these agents:
- N,N-DMT (in case of Cluster Headaches)
- Quetiapine (in case of severe acute psychosis)
- Novocaine + menthol (for very painful stings)
- Ketamine (for severe suicidal feelings)
- Microdosed Ibogaine + cocktail of partial mu-opioid agonists (for acute severe physical pain and panic attack, e.g.. kidney stones)
Some other people would get additional things like:
- Beta blocker (to take right after a traumatic event)
- Agmatine (to take in case you suspect of having being brainwashed recently), and
- Caffeine (if you absolutely need to operate heavy machinery and you are sleep-deprived)
In all cases, the antidote needed would be administered as soon as requested by the wearer. And the wearer would request the antidote as indicated by a very short test done with an app to determine the need for it.
But why? What’s this all about?
The Get-Out-Of-Hell-Free Necklace contents were chosen based on a cost-benefit analysis for how to reduce the world’s Hell-Index as much as possible. Cluster-headaches, kidney stones, bad stings, severe psychotic episodes, suicidal depression, panic attacks, and many types of acute physical pain turned out to account for a surprisingly large percentage of each country’s Hell-Index. And in many of these cases, a substantial amount of the suffering was experienced before medical help could be able to arrive to the scene and do anything about it. A lot of that intense suffering happened to be tightly concentrated in acute episodes rather than in chronic problems (save for some notable examples). And by incredible luck, it turned out that there were simple antidotes to most of these states of agony, all of them small enough to fit in a single light necklace. So it was determined that subsidizing Get-Out-Of-Hell-Free Necklaces was a no-brainer as a cost-effective altruistic intervention.
By 2050 safe and cheap genetic vaccines against almost all of these unpleasant states of consciousness had been discovered. This, in turn, made the use of the Get-Out-Of-Hell-Free Necklaces unnecessary. But many who benefited from it- who had been unlucky enough to have needed it- kept it on for many years. The piece was thought of as a symbol to commemorate humanity’s progress in the destruction of hell. An achievement certainly worth celebrating.
* Admittedly, a more refined index would also distinguish between the intensity of different types of pain/suffering above 20 in the McGill Pain Index (or equivalent). Such index would try to integrate a fair “total amount of hellish qualia” by adding up the pain of each state weighted by its most likely “true intensity” as determined by a model, and then do so for each model you have and weight the contribution of each model by its likelihood. E.g. do both a quadratic and an exponential conversion of values in the 0 to 10 visual analogue scale into dolors per second, and then do a likelihood-weighted average to combine those results into a final value.
[Note: Cross-posted in Qualia Computing]
Agmatine is an aminoacid you can buy over the counter at supplement stores and online. It is used as a workout supplement, to make weed feel stronger, and as a hangover prevention remedy. Agmatine has a high affinity for a number of receptors sites, and it is currently being debated whether it satisfies the criteria for being called a neurotransmitter.
Of particular note is agmatine's high affinity to the imidazoline receptor, which according to Thomas Ray- who analyzed the receptor affinity of 30+ psychedelics- might be one of the keys to the "magic of MDMA". On 2o to 80mg doses on an empty stomach, agmatine does have a nice and very mild positive effect on valence. Mild relaxation, akin to chamomile tea, and mild feeling of social closeness, akin to a glass of wine or a bit of Indica. According to some anecdotal data, and in line with Thomas Ray's predictions, taking agmatine in conjunction with 5HT2A agonists gives rise to a subtle empathogenic effect.
Now, all of that is for background. If you buy a tube of agmatine you will see that the recommended dose is between 500 milligrams and up to entire grams. After all, it is in food and it has an extremely high safety profile. Somehow the general public has missed that on much lower doses it has a nice mild euphoric quality. Anyhow, at the doses typically consumed, agmatine has a distinct blunting effect. As described by people who have both taken SSRIs and agmatine, the effects of high-dose agmatine on pleasurable and noxious stimuli are of the general type of "blunted quality". Emotions feel more fuzzy, music sounds more flat, thoughts seem less deep, philosophy is more boring, and orgasm is less intense. This type of effect (both cutting the top and bottom ends of valence) is what we expect to happen if you add *neural noise* into your nervous system. Like listening to white noise - it is good if the sound it masks is dissonant and unpleasant, but bad if you are trying to listen to a symphony, or to the voice of your loved ones.
It is the blunting effect of agmatine at 0.5 grams+ doses that makes it a great candidate to reduce the impact of brainwashing. Like an SSRI, but much faster and reversibly, agmatine will make whatever multilevel marketing pyramid scheme feelings of guilt and greed you were subjected to kind of melt away and feel more dreamy and less "real". This psychological effect seems to last after the agmatine has been metabolized.