I think the expected value in terms of earnings on for-profit entrepreneurship is much higher than most salaried jobs, maybe with the exception of quantitative trading. (I don’t have a BOTEC for this)
The main objection to this I can imagine is that entrepreneurship offers worse job security (and at least initially, worse pay) than for-profit entrepreneurship.
I think this is true, so I think graduates without dependents who are interested in earning-to-give should take a high paying jobs for 1-2 years to save enough money to support themselves, then spend 1-2 years trying their hand at for-profit start-ups. If it doesn’t seem to be going well and especially if they have dependents, then they should consider switching back to a being an employee.
Another potential objection might be that some or many for-profit start ups do harm, so I think to avoid this EAs should focus on start ups where the direct social impact of the start-up is also net positive.
I think a greater focus on for-profit entrepreneurship for earning-to-givers from an early stage in EA’s history have meant that millions more would have gone to global health charities by now.