I was working on my own list of biorisk reduction project ideas, and ended up creating this list of lists, which seemed silly not to share.
I have quoted a few words describing each project, but it’s well worth clicking through to the original lists. None of them describe projects for longer than two pages, and most for a paragraph or so. Several of the EA Forum posts also contain links for getting in touch with teams working on these projects. If you’re interested in that, you might also want to fill in the longtermist census.
In general, I am so tired of people dying in pandemics. It does not necessarily make me optimistic to see all these project ideas― the world should already be much better at this, and there is so much work to be done. However, it does make me feel hopeful: the world can be much better, and there are projects that you could work on to help it become so.
January 2022 EA Forum Post
Early Detection Center
Early detection of a biothreat increases the amount of time we have to respond (e.g. designing tailored countermeasures, using protective equipment, heading to bunkers, etc)
it seems plausible that with good materials science and product design we could come up with next-generation PPE that is simultaneously highly effective in extreme cases, easy to use, reliable over long periods of time, and cheap/abundant.
“radically improved medical countermeasures against GCBR-class threats, either by 1) producing targeted countermeasures against particularly concerning threats (or broad-spectrum countermeasures against a class of threats), or by 2) creating rapid response platforms that are reliable even against deliberate adversaries
See also: Alvea Vax announcement from Kyle Fish
there is more scope for creative ways of strengthening the treaty (e.g. whistleblowing prizes), or creating new bilateral agreements and avoiding bureaucratic gridlock
Sterilization techniques that rely on physical principles … have the advantage of being broadly applicable, difficult to engineer around, and having little dual-use downside potential
See also: post on UV-C air purifiers
specially designed refuges that safeguard against catastrophic pandemics
As of July 2022
(I have not repeated ideas that pull directly from the above post, though the FTX write-ups are not word-for-word identical)
Crisis-aware regulation for global catastrophic biological risks
public health measures that would have a poor risk-benefit balance in normal times may be warranted or even critical in a crisis in which the benefits to eradicating or delaying a public health threat are unusually large” (link)
See also: original Project Ideas Competition submission by Mackenzie Arnold, with contributions by Kyle Fish
Rapid development and approval of emergency vaccination and therapeutics
imagine a team of high-powered vaccine developers, large-scale manufacturing capability on standby, and ready-to-go infrastructure for rapid human challenge trials in a regulatorily compliant manner” (link)
July 2022 EA Forum Post
Record-keeping for strong attribution
a record-based system for strong attribution of biological agents may be a powerful mechanism to deter biological weapons development and use”
Responsible access to genetic sequences
similar to how patient data is anonymized unless absolutely required, a responsible access system could ensure that [pathogen] genetic sequence fractions are shared with developers of vaccines and other countermeasures that are actually needed”
Consensus-finding on risks and benefits of research
one of the reasons for the debate around… the enhancement of potential pandemic pathogens having stalled is the fact that researchers disagree over the benefits and risks of research… we should try to pool the opinions of different experts to come up with a consolidated estimate”
Information loops to steer funding to less risky projects
“public disclosure of laboratory accidents would likely incentivize better laboratory practices… public disclosure of funding risky research like the enhancement of potential pandemic pathogens might encourage more thorough review and oversight”
The below is a direct quote from the post:
- Improving personal protective equipment (PPE): The design of face masks and other PPE has barely changed for many decades, and still receives relatively little attention. PPE that was highly effective, easy to use, and cheap to distribute would be perhaps the single most transformative technological intervention to overcome biological risks, but is currently laughably neglected.
- Suppressing pathogen spread in the built environment: Indoor spaces are far more dangerous than outdoor spaces for transmitting respiratory infections. While not as general or powerful as improved PPE, interventions to reduce transmission in building could significantly slow the spread of severe biological threats. Proposed interventions in this area include improvements in ventilation, far-UVC irradiation, and upper-room UVGI. However, many of these have significant difficulties to overcome before widespread adoption, and relatively little time and money have gone into either implementing these technologies or identifying promising alternatives.
- Improving biosafety in high-containment labs and clinics: As with PPE for general use, the technologies and systems used to maintain biosafety in high-containment labs and isolation wards are decades old and slow to change. While less important than PPE, improving the other technologies and processes used to contain high-consequence pathogens would help prevent accidental release.
- Suppressing pathogen spread in vehicles: Many of the same principles applied to buildings could also reduce transmission in large vehicles, such as planes and cruise ships. This seems much less important than fortifying buildings against pandemics, but still valuable.
September 2021 report from the Bipartisan Commission on Biodefense
Vaccine Candidates for Prototype Pathogens
by investing in vaccines for at least one prototype pathogen in each of the 25 viral families known to infect humans, we could reduce the global burden of infectious disease while simultaneously preparing for the next unknown biological threat
Multi-Pathogen Therapeutic Drugs in Advance of Outbreaks
previous efforts to develop multi-pathogen therapeutics have largely targeted direct-acting small molecule antivirals. However, new modalities are emerging that may result in increased breadth and potency and which warrant extra investment, including host-directed antivirals and monoclonal antibodies targeting regions conserved across multiple viral species
Flexible and Scalable Manufacturing of Pharmaceuticals
government should broadly invest in the advancement of platform technologies to ensure that therapeutic and vaccine candidates against the next pandemic pathogen can be rapidly manufactured at scale
Needle-Free Methods of Drug and Vaccine Administration
technologies exist that could facilitate the self-administration of drugs and vaccines… microneedle patches have been extensively investigated for influenza vaccine delivery… intranasal or inhalable drugs or vaccines may also enable self-administration… delivery is common for small molecule drugs [but] has seen limited use with biologic drugs and vaccines”
sequencing could become routine in the clinical setting, as well as in high-risk low-resource areas of the world… sequencing could serve as the diagnostic for diseases generally and permit novel pathogen detection early and beyond our borders. All this, while also being robust against genetic changes in pathogens and offering the details needed to track, and ultimately reduce pathogen transmission
Minimally- and Non-Invasive Infection Detection
new sensing capabilities such as non-invasive volatolomics (the detection of volatile compounds emitted by an individual) and wearables could permit constant passive monitoring of markers of infection without interfering with or inconveniencing our daily lives Massively Multiplexed Detection Capabilities bring new benefits by simultaneously testing for multiple pathogens, resistance genes, biomarkers, and analytes in a single simple assay. Massively multiplexed detection capabilities in the form of pan-viral and pan-microbial assays have also been demonstrated, ushering in a new paradigm for diagnostics
Rapid Point-of-Person Diagnostics
Point-of-person diagnostics stand in contrast to clinically administered diagnostics, which often require transportation to centralized laboratories, and days or weeks before rendering results
Digital Pathogen Surveillance
digital pathogen surveillance systems, which use internet-based and other electronically available data (e.g., medical bulletins, search queries, social media)... have the potential for near real-time warning ability, international detection, and automated operation
A National Public Health Data System
Although it is an enormous undertaking, a National Public Health Data System [for the USA] would provide the capabilities needed to effectively address the spectrum of biological threats
An Integrated National Pathogen Surveillance and Forecasting Center
An integrated real-time national pathogen surveillance and forecasting center with advanced capabilities to detect and model naturally occurring, accidentally released, and intentionally introduced biological threats does not currently exist
Next-Generation Personal Protective Equipment
innovations in the following areas: 1) reusable, sterilizable, and self-disinfecting equipment; 2) modular designs responsive to a wide range of threats; 3) personalization to ensure adequate protection, comfort, and attractiveness; 4) rapid production from widely available materials without supply vulnerabilities; 5) the ability to neutralize pathogens; 6) sensing capabilities to detect potential exposures; and 7) protection beyond traditional masks, respirators, gloves, gowns
Pathogen Transmission Suppression in the Built Environment
Suppressing pathogen transmission, especially in high-risk and high-traffic spaces, would reduce the spread of infectious diseases, extinguish some outbreaks, and buy critical time to combat more aggressive pathogens
Comprehensive Laboratory Biosafety
Our risk tolerance in laboratories worldwide working with biological threats should be comparable to that of air travel, where safety is engineered into the airlines and airports, and monitoring occurs constantly to detect and prevent human-generated and technology-based accidents
Technologies to Deter and Prevent Bad Actors
The ability to investigate, analyze evidence, and attribute deliberate biological events is essential for both deterrence and response… Unfortunately, biological attribution, genetic engineering detection, and microbial forensic techniques have only made small strides since the anthrax attacks of 2001”
Johns Hopkins Center for Health Security, October 2018 report
(this is an older list; I've included 11 out of 15 ideas)
- Ubiquitous Genomic Sequencing and Sensing: near-real-time characterization of pathogen biology
- Drone Networks for Environmental Detection: networks of drones autonomously conducting environmental surveillance for biological disruption to important ecosystems and bioterrorism
- Remote Sensing for Agricultural Pathogens: advanced satellite imaging and image processing technologies for ongoing, widespread, systematic agricultural surveillance
- Microfluidic Devices: “lab on a chip” diagnostic devices to augment or replace traditional laboratory testing
- Handheld Mass Spectrometry: a handheld, truly portable unit that can provide advanced diagnostic capabilities in the field and at the point of care
- Cell-Free Diagnostics: generate rapid colorimetric outputs visible to the naked eye for easy interpretation
- 3D Printing of Chemicals and Biologics: for distributed manufacturing of MCMs as well as personalized drug dosing and formulation
- Microarray Patches for Vaccine Administration: an emerging vaccine administration technology that has the potential to modernize the conduct of mass vaccination campaigns
- Ingestible Bacteria for Vaccination: bacteria placed inside temperature-stable capsules, and engineered to produce antigens in a human host; can be self-administered in the event of a pandemic
- Drone Delivery to Remote Locations: drone transportation networks can enable the rapid delivery of clinical materiel and pharmaceutical supplies
- Portable, Easy-to-Use Ventilator: an inexpensive, portable mechanical ventilator with an intuitive and largely automated user interface
Other lists that aren't exactly of concrete project ideas
The aim of this post is to provide lists of project ideas, not to provide a complete view of the entire space of projects relevant to mitigating global catastrophic biorisks. There are a lot of people doing and funding concrete biosecurity projects! That said, here are a few more places you might look for inspiration as you think about what to prioritise.
Lists of EA biosecurity grants
- Open Philanthropy Grants in Biosecurity & Pandemic Preparedness
- Full list of FTX Future Fund grants and regrants in the Biorisk and Recovery from Catastrophe focus area
- The Long Term Future Fund has public payout reports though you can't subset by cause area
Lists of research questions more than projects
- Project Ideas in Biosecurity for EAs, a February 2021 forum post that lists ideas in economics, sociology/anthropology, meta-science, law, public policy, and epidemiology
- 80 questions for UK biological security, a January 2021 journal article that used expert elicitation to identify "the questions most critical to effective and coordinated progress in different disciplines of biological security"
- Request for proposals: Help Open Philanthropy quantify biological risk, a May 2022 RFP that includes a number of research ideas under "what a successful proposal might look like"
Concrete projects prioritized by specific organizations
NTI’s Biosecurity Innovation and Risk Reduction Initiative has the following working groups:
- Common Mechanism to Prevent Illicit Gene Synthesis
- Financial Incentives for Biotechnology Investors to Improve Biosecurity
- Standards for Funders, Grantees, and Publishers to Identify and Mitigate Biological Risks
- Establishing a Seal of Approval to Incentivize the Adoption of Biosecurity Norms
- Insurance Incentives for Reducing Biological Risks
CEPI’s End Pandemics Investment Case outlines the following priorities:
- Compress vaccine development timelines to 100 days
- Develop a universal vaccine against coronaviruses
- Develop a library of vaccines against other threats (i.e. viruses from the 25 viral families implicated in human disease)
Kevin Esvelt's lab works on relevant concrete projects, including some (such as the Nucleic Acid Observatory) mentioned above.
If you know of other lists of project ideas, please share them in the comments and I will try to incorporate them into the post!