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Thanks for this interesting stuff! I like that stat about 10% of diseases causing over 50% of the morbidity/mortality, and eradicating those having a much smaller cost. For that reason me that 1.4 trillion number to potentailly eradicate 50% of the might be more important than the 14 trilllion one.

I'll have a look at the lancet paper - I don't really understand the 8.5 billion being needed to "maintain" the situation after malaria is eradicated, I thought the definition of eradication was that it was gone (like smallpox) - so would no longer need money pumped into it. Perhaps they are assuming malaria remains in animals continuing the life cycle?

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$14t BOTEC cost to eradicate all infectious diseases

by marvolopanda

May 13 20241 min read 5

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BiosecurityGlobal health & development

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In March, Max G suggested someone write a back of the envelope calculation for eradicating all infectious diseases. I think it would cost about $14 trillion.

Malaria: A 2018 study in The Lancet estimated that eradicating malaria by 2050 could cost $100 billion, with annual costs of $8.5 billion after eradication to prevent resurgence.
Polio: the total cost since 1988 is in the tens of billions of dollars.
Tuberculosis: A 2014 study estimated that ending the global tuberculosis epidemic by 2035 would require an additional $56 billion in funding.

Based on the above, ballparking an average cost of eradication of $10 billion per disease, the total cost for eradicating all 1,400 known human pathogens would be around $14 trillion.

It's estimated that a relatively small percentage of these pathogens, perhaps around 10% or about 140, are responsible for the majority of infectious diseases in humans. To eradicate those, the total cost would be $1.4 trillion.

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rileyharrisMay 13 20246

This is a cool idea, I upvoted (from -1 to 0). I'd really like to see more detailed analysis and well-documented sources to answer this question. I couldn't really tell from the post whether the numbers were about right or not.

I worked on a report with others at Longview. We calculated that severely reducing the burden of HIV, Malaria and Tuberculosis would be around $219 billion. Essentially, we adjusted numbers from a variety of reports from e.g. the WHO to estimate these numbers (possibly some of the same sources, it's hard to tell). This is already quite a bit more than the $10 billion estimate you have. I think the main difference is due to adjusting for inflation and in-kind medicine donations.

However, this wouldn't allow us to eradicate these diseases in all likelihood. In fact, the target for Tuberculosis was to reduce deaths by about 90%. It is plausible that the last 10% is actually much more expensive to target, because the low hanging fruit has been picked, so to speak. (I'm not an expert in this area, and this could be completely wrong).

This makes me think that the cost of eliminating these diseases is likely well over $100 billion each.

(We also estimated the costs of severely reducing the burden of disease from neglected tropical diseases, and that was lower per disease.)

NickLaingMay 13 20243

Hey Riley. I think the 10 billion is on average "per disease", in the post they listed 100 billion as the number for malaria which is in the ballpark of your estimates.

NickLaingMay 13 20244

JoshuaBlakeMay 13 20243

Why are you ballparking $10b when all of the examples given are many multiples of that? $100b seems like a better estimate.

I also suspect we're targeting easy to eradicate diseases. Those without animal reservoirs that will cause resurgences and where there are effective interventions. Therefore, I'd suggest this is a lower bound.

Matt_SharpMay 14 20241

I'm also confused as to why $10bn per disease is suggested, given the much higher costs of the listed examples.

However, it seems plausible that costs per disease will substantially decrease as we learn more about biology and how to successfully run eradication campaigns. For example, developing a new vaccine technology against one virus could make it much easier and cheaper to develop vaccines against related viruses.