As noted by Sam Nolan here:
GiveWell's cost-effectiveness analyses (CEAs) of top charities are often considered the gold standard. However, they still have room for improvement. One such improvement is the quantification of uncertainty.
Why does GiveWell not provide lower and upper estimates for the cost-effectiveness of its top charities?
That seems pretty high to me! When I've seen GiveDirectly used as a point of comparison for other global health/poverty charities, they're usually described as 1-10x more effective (i.e. people care about distinctions within one order of magnitude).