CEA has just launched the 2018 Donor Lottery with block sizes $100k and $500k.
A donation lottery is a different way to donate. Rather than making a donation to a charitable organization directly, you can make a donation to a donor lottery. You then get a shot at being able to recommend where the entire pool of money goes, in proportion to the size of your donation.
See the link for more information, including a gratuitously technical methodology section to convince you we can't put our finger on the scales.
At the link you can also see the last year's lottery and draw that gave the first block to Adam Gleave. Here's his writeup of his decision on where to donate.
Please feel free to comment with any questions, though perhaps check if they were answered in last year's announcement.