What videos should Rational Animations make?

Require people building biospheres to stick nanotech in the brains of anything that can feel pain to make sure it doesn't get bad enough to stop being fun?

I don't think this is the place that a soft negative utilitarian actually breaks with a soft total utilitarian transhumanist.

Interesting! One idea they could expand on is that spreading to other stars would mean that the probe we send could later come back to kill us all. Basically, "humans" or probes on other stars would evolve differently from us, and it would take crazy long periods of time to communicate with them. It would be near impossible to coordinate an interstellar civilization, even with light-speed travel.

Worldbuilding contest #2 winner here, would be happy to collaborate!  Here is an (AI-risk and "inadequate equilibria" focused) blog post summarizing my team's entry: A bridge to Dath Ilan? Improved governance on the critical path to AI alignment.  Although I note that FLI is already slowly working on producing some kind of media follow-up to the contest entries -- at least podcasts, and maybe videos or other products.

Considering how awesome your video on Prediction Markets is, I also think it could be a great idea to make videos about some of the institutional innovations that my worldbuilding scenario is built around -- charter cities / network states, alternate voting systems like approval voting and liquid democracy, and so forth.  (If you want to take things in an even more political direction, you could produce animated versions of the Bryan Caplan arguments for open borders or YIMBYism.)

For some more traditionally rationalist / EA media ideas, here are two of my comments on some previous threads about the idea EA documentaries.

Craziest idea: make a video about HPMOR -- either a movie-trailer-style animation, or a longer more traditional youtube-y style summary of the early parts of the story, and hope that this works as a short hook to get more people reading the whole thing?  Thus leveraging the amount of rationalist content you imbue per unit of animation effort.  (I feel like the idea of video-as-hook would work well for HPMOR and other works of fiction, versus with other EA / rationalist content it is better to stick to "video as summary of the key message".)  Idk about the copyright issues here though.

On the subject of fiction, how about illustrating some much-shorter-than-HPMOR stories from the (allegedly slim) pantheon of great EA & rationalist fiction works?

• Fable of The Dragon Tyrant has already been done -- but it got 9M views!! 
• The metaphor in "500 Million, But Not A Single One More" is very similar to "The Dragon Tyrant", and it would probably work well with RationalAnimation's style of illustrating ideas using monsters and leviathans (like in your "Transparent Tragedies" episode).
• "The Drowning Child and the Expanding Circle" isn't a fiction story that could be transcribed word-for-word, rather it's a thought experiment.  But it would make for a great hook for a video that goes on to explain basic EA concepts. 
• Similarly, just illustrating the "paperclips" AI thought-experiment (detailed and realistic rendition here, shorter and less-realistic versions found in many places including the clicker game "universal paperclips", which became quite popular) could be very valuable, and I feel like it would fit well with the tone of RationalAnimations' existing videos about aliens, apocalypses, and other big-picture high-drama topics.
• I feel like there are a LOT of different angles that you could take when making videos about superintelligence / AI.  But this comment is already long so I will not try to enumerate them here.
• Since your audience loves Robin Hanson content so much, give them a summary of Age of Em?  Although this is not a super-relevant subject matter.
• If the copyright issues around HPMOR are navigable, consider adapting the EA short-story "A Common Sense Guide to Doing the Most Good", which is like the rational-fiction version of this famous SMBC comic where superman turns a crank all day to generate power -- in real life, superman could do good much more effectively than turning the crank!
• Or how about a story where you use the vivid, apocalyptic details of the Toba Supervolcanic Eruption as a way to both inform viewers about the real history of humanity's near-extinction 75,000 years ago, AND as a metaphor about the importance of longtermism and humanity's vast potential?  Again, I think this would fit well with the themes of other videos by RationalAnimati-- oh, no!  My comment has looped back around from helpful brainstorming to the very same shameless self-promotion with which I started off!!