85% of Americans over the course of their lifetime will have their third molars, also known as their wisdom teeth, removed.
In supply chain management, a fun game to play is “five whys”. It means that when there’s a problem, you try to ask “why” at least five times to get to the root cause. Let’s try to apply this to a patient with pain in his upper jaw.
Why does the patient have pain in their upper jaw? Because their wisdom tooth is impacting their second molar.
Why is their wisdom tooth impacting their second molar? Because their upper jaw isn’t large enough for it to grow straight down.
Since the patient’s jaw is too small to accommodate the tooth, it cannot be made to point upright using braces or other methods. So, the tooth is extracted.
The thing that baffles me is, what is with the lack of curiosity about why the patient’s jaw is too small? We did not evolve in an environment where tooth extraction was easy or risk-free. So why would we evolve wisdom teeth that need to be extracted? It turns out, we didn’t.
From the article “Evolution of human teeth and jaws: Implications for dentistry and orthodontics”, published in 2012 in the journal Evolutionary Anthropology, the authors say:
Like caries and, probably, periodontal disorders, malocclusion is a ‘‘disease of civilization,’’ being much less common in fossil hominins and traditional foragers. Third-molar impaction for instance, occurs ten times more frequently in industrialized peoples than in hunter-gatherers. Further, fossil hominins and recent foragers tended to have an edge-toedge incisor bite rather than procumbent uppers overjetting lowers. The basic problem is a mismatch between jaw length and tooth size; there is insufficient room for proper implantation of our back teeth, so the front ones are pushed forward or forced out of proper alignment.
Put simply, fossils and traditional foragers don’t seem to have underbites, overbites, or problems with their wisdom teeth nearly as often as people in modern societies. Either our jaws have gotten smaller or our teeth have gotten bigger.
The standard hypothesis is that our teeth have gotten bigger. People in industrialized societies have less wear on their teeth, compared to foragers and hunter-gatherer fossils. Since wear makes your teeth smaller, that seems to explain the mismatch.
But the authors then go on to say:
It seems more likely, however, that our jaws are underdeveloped because softened, highly processed foods do not provide the chewing stresses needed to stimulate normal growth of the jaw during childhood. Human jaws have become shorter, on average, since the Paleolithic, a trend that is also seen in recent foragers who have made the transition to an industrial-age way of life.
This is reminiscent to me of trees that are grown indoors. When a sapling is pushed by the wind, it releases a hormone that helps it grow stronger. Trees that are grown indoors, where there’s no wind, will not do this and will break more easily in adulthood.
The obvious question is: if an underdeveloped jaw causes crowding, does it also cause other problems? I have some personal experience here, because I had my jaw surgically expanded when I was 22. (This is done over the course of a few months using something called an MSE appliance.) My opinion is that an underdeveloped upper jaw is a source of many problems.
The first problem is that it can prevent your tongue from suctioning to the roof of your mouth. That means that when you sleep, your tongue can fall back into your throat, causing snoring and sleep apnea. Sleep apnea is then treated with CPAP machines, which are expensive and inconvenient.
The second problem is that it results in a smaller nasal airway. Look at the difference in nasal airway size for this woman, who had her upper jaw expanded three times:
A small nasal airway limits the amount of air that can pass through your nose, encouraging you to breathe through your mouth. As it is impossible to breathe through your mouth while your tongue is suctioned, this also contributes to sleep apnea.
I suspect a small nasal airway is also easily clogged by mucus. Before I had my jaw expanded, I regularly had to change which side I slept on as one nostril or the other would get clogged. That hasn’t happened once since, even when I’ve gotten sick.
There is some evidence that the tongue’s pressure on the teeth when in suction also contributes to jaw development. The main evidence is the study Primate Experiments on Oral Respiration, where experimenters forced monkeys in the experimental group to breathe through their mouth by blocking their nasal airway.
All experimental animals gradually acquired a facial appearance and dental occlusion different from those of the control animals.
…
The common finding was a narrowing of the mandibular dental arch and a decrease in maxillary arch length
It’s possible that the improvements in nasal airway size are only the result of jaw-expansion surgery, and would not happen as a result of expanding the jaw naturally through chewing chewier foods in adolescence. I doubt it, and I’ll make a bet: $10 says hunter-gatherer fossils and modern-day foragers have larger nasal airways than people in industrialized societies.
It seems likely that many of these problems could be avoided if parents encouraged children to eat chewier food. Parents whose children breathe through their mouth should get their children examined for tongue-ties, macroglossia, and nasal obstructions. Finally, children experiencing crowding should be treated with expanders rather than extractions whenever possible. These interventions are cheap and mostly bottlenecked on improving awareness.
With recent FTX news, EA has room for more billionaire donors. For any proposed EA cause area, a good standard question to ask is: "Could this be done as a for-profit?" Quoting myself from a few years ago:
Before anyone jumps on me here: IMO, an important takeaway from the FTX catastrophe is that EA-founded businesses should avoid mentioning EA in their marketing by default. Even if you think you have a good reason to use EA in your marketing, you should still get CEA's permission first.
Other good ways to not be like SBF include: Have detailed knowledge of what people are buying and accurately communicate it to customers, including your own uncertainty. Pay special attention to identifying and mitigating ways in which your product could do harm (e.g. for a chewy food product, choking is an obvious potential hazard). Do these things beyond what's required by law, and what's pragmatic from the point of view of maximizing profit. Be willing to pull the plug on the business proactively if risks seem too high, or things aren't going in a good direction.
If you aren't able to achieve healthy profits while respecting such ethical guidelines, that's an indicator that the business idea isn't promising and you should find something else. Good business ideas are in "blue oceans" with little competition, plus somewhere you can build a durable competitive moat, meaning you won't be caught in a race to the bottom.
Anyway, back to the post. Your proposed interventions are "mostly bottlenecked on improving awareness". In the business world, awareness is achieved through marketing. You could sell a product which helps kids with jaw development, and your marketing could improve awareness of this problem as a side effect.
What product could you sell? Perhaps some sort of kid-themed chewy snacks -- a nutty animal cracker? Or maybe a long, thin stick to minimize choking risk (with spiky sides so even if it gets caught in the throat they can still breathe around it?) Maybe the snacks could come in grades of chewing difficulty, so you can put your kid on a step-by-step program of jaw development, gradually ramping them up from the soft foods they're eating right now.
It'd be very tempting to promote this by saying: "buy this $10 snack and you could save thousands on orthodontics down the road". That could be an amazing sales pitch. But you want to be very careful in making any kind of health claim. There are lawyers who specialize in navigating FDA regulations around such claims. Maybe you'd want to start with a study measuring your product's impact on some sort of near-term proxy for jaw development, as a basis for eventually making such a claim.
In terms of the professional treatment side, you could build a directory of dentists who e.g. work with expanders instead of doing extractions. Then create a tool that helps a parent find such a dentist in their area, solicit dentist reviews from parents, advertise your tool, and make money through lead generation.
Interesting points.
I could see this going the other way as well. Maybe EAs would've felt more free to criticize FTX if they didn't see it as associated with EA in the public mind. Also, insofar as FTX was part of the "EA ingroup", people might've been reluctant to criticize them due to tribalism.
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