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Not with a bang, but with a quadrillion tiny robots

The year is 2038. A large company has spent the last 18 years developing an additive nanofactory that can produce and scan almost any object at the atomic scale, using a supply of "element cartriges" which contain base elements and compounds that are easily broken into base elements (e.g. graphite, ammonia, silicon crystals, water, table salt). The company worked with a university to develop advanced algorithms, published freely in open-access scientific literature, for constructing virtually any molecule or molecular lattice from the elements in the cartrige, including proteins (though it is not optimized for this, as there are already other companies that specialize in bioengineering). Each factory can produce objects up to one cubic centimetre in size in a vacuum-sealed chamber, and printing something so large could require up to 2 or 3 weeks. The units also have a "3D scan" ability that builds an atomic-scale model of any outer surface by "feeling" it; this ability is also used during 3D printing to verify that the object isn't moving during fabrication, or, if the object moves, to characterize and potentially correct the problem. The units, which supercede a simpler and less flexible model, have just gone on sale for $10 million apiece. Several universities and companies order one.

In 2040, a millionaire who loves nanotechnology wants to democratize the technology, dreaming of various benefits it could bring to the world. He hires a chip designer, a nanotechnology expert and a few grad students enthusiastic about the technology, and starts a small business that designs a USB-C powered Nanofab™ based on a royalty-free nanoconstructed silicon RISC-V chip and a Linux-based OS in flash storage, plus a custom ROM designed to help load the initial firmware (as electron patterns cannot be 3D printed). Its external dimensions are 7mm x 11 mm x 4 mm and it can build objects up to 7 mm x 3 mm x 2 mm in size; it is about the same speed as the original factory it was made from, and supports 3D scanning too. In particular, the factory is designed to make hand-assembled copies of itself, by producing and ejecting a sequence of 8 pieces over 7 days, which a person can snap together into a complete unit. One must place an element cartridge on top, which is twice the size of the factory itself; the empty cartridge is also designed to be constructed by the factory and it has a connector allowing it to be quickly filled from a larger cartridge.

The millionaire's company is located in rented office space next to a university, from which it rents blocks of time on one of the university's nanofactory units. Three months after completing and testing the first factory, the office is filled with over a thousand Nanofabs, all spawned from the first copy ever made. Employees tire of snapping together factories by hand, so they rent a house and hire low-wage employees to spend their days snapping together factories and cartridges for sale to the public, while the office remains devoted to technology development. Factories with cartridges initially sell for $75 each, and refills cost $30. The blueprints for the factory are free for noncommercial use, but the cartridges are patented, proprietary modules that must be purchased (along with raw elements) from the company. The company puts service booths in malls for selling Nanofabs™ and refilling cartridges, though it also sells everything online.

By 2052 the millionaire is a billionaire, and other companies spring up to sell competing cartridges, raw materials, and eventually, high-speed nanofactories. Nanofabs are soon used by millions of people and companies for printing a vast assortment of tiny devices, from skin-adhesive smartphones, to contact lenses that can record and transcribe video/audio of every moment of every day, to carbon-fiber "ringguns", small untraceable handguns that attach to a pair of human fingers. Meanwhile, a field of "artificial life" emerges, illegal nanofabricated drugs are rampant, the presidents of China and/or Russia have long since given themselves absolute power (while maintaining a pretense that they haven't), and research into AGI has started to bear fruit....

Question: how might these developments lead to the end of human civilization? Is it more likely to be destroyed by AGIs or humans? What if the original technology hadn't been so open - might one group of humans or AGIs gain a supreme technological advantage over everyone else, or does this just delay the democratization process?

Do you see evidence from 2020 technology that such technology could be developed by 2038, with even a low probability?

Of course, even a longer development timeline could end with many of the same problems. But it seems likely that these problems are smaller-scale than those we would expect to see from misaligned artificial intelligence. We already have examples of countries where one or more of guns, surveillance, and drugs run rampant, and I don't immediately see the connection to catastrophic risk. 

It's unclear to me whether nanotechnology really makes it much easier for humans to harm each other, or whether a superintelligent AI would become much more threatening with this technology than without it (especially since it would presumably be easy enough to build in a future advanced society, whether or not humans had built it first).

Your questions are good ones to ask, and similar to questions being asked about AI in many EA-affiliated research institutions. I'm not an expert in that space, but you might be interested in subscribing to the Alignment Newsletter if you aren't already and want a good sample of the work being done.

After further thought, I decided 2038 was probably at least a few years too early for the highly general-purpose nanotechnology I described. Still, people may be able to go a long way with precursor technologies that can't build arbitrary nanostructures, but can still build an interesting variety of nanostructures.

Meanwhile I would be surprised if a superintelligent AGI emerged before 2050—though if it does, I expect it to be dangerously misaligned. But I have little specific knowledge I could use to estimate nanotech timelines accurately, and my uncertainty on AGI is even greater because the design space of minds is so unknown — AFAIK not just to me but to everyone. This AI alignment newsletter might well improve my understanding of AGI risk, but then again, if there were a "nanotech risks newsletter", maybe it would teach me how nanotech is incredibly dangerous too.