UPDATES:
- We just launched a new substack, called Curing Addiction.
- And here's a new EA forum post with the latest on what we're doing.
Hi
I'm working on a research, policy, and advocacy project that's looking at breakthrough treatments for opiates, cocaine, and alcohol addictions and overdoses. There are radical new treatments in development, including several in Phase I, such as:
• Vaccines for fentanyl, heroin, cocaine, and oxycodone
• More effective non-opiate painkillers
• Drugs that reduce addictiveness and craving
My growing belief is that (1) negative impact of the addiction crisis in the US and around the world is underestimated, (2) breakthrough medical treatments are the only realistic way to actually solve the problem, and (3) research and development of these treatments is radically and irrationally underfunded (see the NIH HEAL Initiative for some funding that is happening). At this stage, I'm working to put together strong evidence for all three points.
And I'm looking for help! The goal is to build a powerful argument that this space lacks funding and political urgency relative to its potential and then advance that case to the public and policy makers. I've been doing some writing that may become a public substack and have done a lot of research already on the state of the field and the key players. I don't think this information has been brought together anywhere publicly before.
My background is in public policy and tech-- I went to Brown for public policy, started and ran award-winning open-source and tech rights advocacy non-profit organizations, and then had a successful run in for-profit tech, which has given me the ability to choose my next project without worrying about income. I also have a science background so I'm able to read and understand the literature on these emerging treatments to a moderate level of granularity.
I'm making good progress myself but could use help in a few areas and I think having a small team of folks who are volunteering together could work really well and would be pretty fun.
Skills I'm looking for:
• It would be great to have someone looking at the numbers and building the analytic case for investment. For example, I believe that in the US overdoses are the 3rd largest cause of years of life lost behind only heart disease and cancer, but I need a little help locking down the numbers on that since the overdose stats are buried within 'accidents' mortality reporting. Similarly, I want to quantify some costs of the drug war on global development, impact of drug related crime in the US and globally, etc etc.
• A biology PhD would be great to have on this ragtag squad.
• Anyone with professional expertise in health policy would be super helpful.
• Anyone with professional experience in bringing drugs to market would be very helpful for evaluating timelines and likelihood of approval for various treatments, as part of building the case for increased investment.
• Someone who is good at turning numbers into clean charts and graphics would be very helpful for making strong presentation materials.
If you're interested or have questions or suggestions or know of resources that have addressed this topic that I may have missed, please message me on the forum! I'm new here, so I apologize if I'm not familiar with forum practices and etiquette.
I think you could build a very compelling case for this. Even if official data sources do underestimate key numbers like overdose deaths, they are still a stirring call to action.
2. Other "similar" problems are not getting worse. Other "despair" indicators like suicide and depression appear to be stable. Road accidents and violence have fallen. On one hand it's a bit sneaky to pick and choose comparisons like this, but it could be argued that they are all societal problems that often cause (very) early death. They're tragic.
3. Vaccines/ other pharma interventions may offer an unusually tractable and scalable solution. Addiction and all of the other problems in the chart above are very difficult problems to fight. At best, interventions usually take a chunk out of the burden but offer no hope of big change. Drug interventions can be controversial, with effects of uncertain sign. If you can show that your ideas are significantly better, you are doing well.
I expect that a major difficulty is that your solutions involve developing new vaccines/drugs, which is of course an expensive, unknown and long process. Will pharma companies see potential for a profit? Is there scientific grounding for optimism on these new drugs being possible?
Unfortunately I don't have the spare capacity to volunteer much time. I'd be interested in giving feedback on any future work. Good luck!
Thanks Stan, I really appreciate it! I have several short articles that I'm writing covering various aspects of this and will reach out to get your feedback when I'm closer.
On question 3-- yes, I think there is reason for optimism that the new treatments under development can work, including vaccines, non-opiate painkillers, addiction reducers, etc. Il'l be writing about this very soon and also looking for experienced pharma folks for thoughts on pipeline to market timing and obstacles.
Whether these treatment will be game-changers or useful additions to our limited toolbox remains to be seen. And whether they will take 15 years to get to market or 5 is what I'm hoping to influence. But there are some human trials already in progress on exciting stuff.